CAS 1094614-84-2

3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide

CAS: 1094614-84-2

Formula: C₂₅H₂₄N₄O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 412.4837

Ref: IN-DA0039K6

(E/Z)-BIX02188

CAS: 1094614-84-2

(E/Z)-BIX02188

Purity: ≥95%

Molecular weight: 412.48g/mol

Ref: 54-BUP05003

BIX-02188(Random Configuration)

CAS: 1094614-84-2

BIX-02188(Random Configuration)

Molecular weight: 412.48g/mol

Ref: 54-BISN0211

(E/Z)-BIX02188

CAS: 1094614-84-2

BIX02188 inhibits MEK5 (IC50: 4.3 nM) and ERK5 (810 nM) but not MEK1/2, JNK2, or ERK2.

Formula: C₂₅H₂₄N₄O₂

Purity: 97.39% - 98.38%

Color and Shape: Solid

Molecular weight: 412.48

Ref: TM-T6324

BIX 02188

CAS: 1094614-84-2

A selective inhibitor of MEK5 protein kinase with an IC50 value of 4.3 nM. Blocks transcriptional activation of myocyte-specific enhancer factor 2C (MEF2C). Inhibits phosphorylation of ERK5 protein kinase and thereby reverses inhibition of TNF signaling induced by fluid shear stress in endothelial cells. Induces apoptosis in FLT3-ITD cells.

Formula: C₂₅H₂₄N₄O₂

Purity: Min. 95%

Molecular weight: 412.18993

Ref: 3D-FB64959

BIX02188

Controlled Product

CAS: 1094614-84-2

Applications BIX02188 MEK inhibitor, prevents cell proliferation and induces apoptosis. Can be applied towards treatments of cancers and proliferative cell diseases.
References Tatake, R. et al.: Biochem. Biophys. Res. Comm., 377, 120 (2008);

Formula: C₂₅H₂₄N₄O₂

Color and Shape: Neat

Molecular weight: 412.48

Ref: TR-B591685