CAS 1095173-27-5

N-[(2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N′-(4-cyanophenyl)urea

Description:

N-[(2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N′-(4-cyanophenyl)urea, identified by its CAS number 1095173-27-5, is a chemical compound characterized by its complex structure, which includes a benzimidazole moiety, a piperidine ring, and a cyanophenyl group. This compound is typically classified as a urea derivative, which suggests potential applications in medicinal chemistry, particularly in the development of pharmaceuticals. The presence of the benzimidazole ring is often associated with biological activity, including antimicrobial and anticancer properties. The piperidine component may contribute to its pharmacological profile, influencing its interaction with biological targets. Additionally, the cyanophenyl group can enhance lipophilicity, potentially affecting the compound's solubility and permeability. Overall, this compound's unique structural features may provide insights into its reactivity, stability, and potential therapeutic applications, making it a subject of interest in drug discovery and development.

Formula: C₂₁H₂₂N₆O

InChI: InChI=1S/C21H22N6O/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28)/t16-,19-/m1/s1

InChI key: InChIKey=SFNSLLSYNZWZQG-VQIMIIECSA-N

SMILES: CN1[C@@H](C=2NC=3C(N2)=CC=CC3)C[C@H](NC(NC4=CC=C(C#N)C=C4)=O)CC1

Synonyms:

• Glasdegib
• N-[(2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N′-(4-cyanophenyl)urea
• Urea, N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N′-(4-cyanophenyl)-
• PF 04449913

Glasdegib

CAS: 1095173-27-5

Glasdegib

Purity: ≥98%

Molecular weight: 374.44g/mol

Ref: 54-BUP02848

1-((2R,4R)-2-(1H-Benzo[D]Imidazol-2-Yl)-1-Methylpiperidin-4-Yl)-3-(4-Cyanophenyl)Urea

CAS: 1095173-27-5

1-((2R,4R)-2-(1H-Benzo[D]Imidazol-2-Yl)-1-Methylpiperidin-4-Yl)-3-(4-Cyanophenyl)Urea

Purity: 98+%

Molecular weight: 374.44g/mol

Ref: 54-OR1024366

Glasdegib

CAS: 1095173-27-5

Formula: C₂₁H₂₂N₆O

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 374.44

Ref: 7W-GX0918

Glasdegib

CAS: 1095173-27-5

Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.

Formula: C₂₁H₂₂N₆O

Purity: 98.72%

Color and Shape: Solid

Molecular weight: 374.44

Ref: TM-T6514