CAS 109528-49-6

hirudin fragment (tyr(so3H)63)-*fragment 54-65

Description:

Hirudin fragment (Tyr(SO3H)63)-fragment 54-65, with CAS number 109528-49-6, is a synthetic peptide derived from hirudin, a potent anticoagulant protein originally isolated from leeches. This specific fragment is characterized by its sequence of amino acids, which includes a sulfated tyrosine residue at position 63, contributing to its biological activity. The sulfation enhances the peptide's interaction with various proteins, particularly those involved in blood coagulation, thereby increasing its anticoagulant properties. Hirudin and its fragments are known for their ability to inhibit thrombin, an enzyme critical in the coagulation cascade, making them valuable in therapeutic applications for preventing thrombosis. The fragment's structure typically includes a combination of hydrophilic and hydrophobic regions, influencing its solubility and interaction with biological membranes. Additionally, the presence of the sulfate group can affect the peptide's stability and bioavailability. Overall, this fragment serves as a model for studying anticoagulant mechanisms and developing new therapeutic agents.

Formula: C₆₆H₉₃N₁₃O₂₈S

Synonyms:

• Hirudin (54-65) (sulfated)
• H-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr(SO3H)-Leu-Gln-OH

Hirudin (54-65) (sulfated)

CAS: 109528-49-6

Hirudin is a protein that functions as an anticoagulant by binding to the active site of thrombin, preventing it from converting fibrinogen into fibrin. It has a high affinity for the thrombin receptor and can be modified in various ways. Hirudin's most common modification is sulfation, which enhances its anticoagulant activity. Hirudin is a proteolytic enzyme that can be synthesized using solid-phase chemistry. Its biological function is to inhibit blood coagulation by inhibiting the conversion of fibrinogen to fibrin. Hirudin binds to thrombin, preventing it from converting fibrinogen into fibrin and thus inhibits coagulation. It also prevents clot formation by inhibiting platelet aggregation, which may result from interactions with other proteins such as prothrombin and factor VIII.

Formula: C₆₆H₉₃N₁₃O₂₈S

Purity: Min. 95%

Molecular weight: 1,548.58 g/mol

Ref: 3D-FH110098

Hirudin (54-65) (sulfated)

CAS: 109528-49-6

Bachem ID: 4014553.

Formula: C₆₆H₉₃N₁₃O₂₈S

Purity: 96.6%

Color and Shape: White Lyophilisate

Molecular weight: 1548.6

Ref: 01-4014553