CAS 109581-93-3
:Tacrolimus hydrate
Description:
Tacrolimus hydrate, with the CAS number 109581-93-3, is an immunosuppressive agent primarily used in organ transplantation and autoimmune diseases. It is derived from the bacterium Streptomyces tsukubaensis and functions by inhibiting T-lymphocyte activation, thereby reducing the immune response. The substance appears as a white to off-white powder and is soluble in organic solvents such as methanol and dimethyl sulfoxide, but has limited solubility in water. Tacrolimus hydrate is often formulated as a topical ointment or oral medication, depending on its application. Its pharmacological effects are attributed to its ability to bind to FKBP-12, a protein that subsequently inhibits calcineurin, a critical enzyme in T-cell activation. While effective, tacrolimus can have side effects, including nephrotoxicity and increased susceptibility to infections, necessitating careful monitoring during treatment. Overall, tacrolimus hydrate is a vital therapeutic agent in managing conditions requiring immune suppression.
Formula:C44H69NO12·H2O
InChI:InChI=1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1
InChI key:InChIKey=NWJQLQGQZSIBAF-MLAUYUEBSA-N
SMILES:O(C)[C@@H]1[C@@]2(O[C@](O)([C@H](C)C1)C(=O)C(=O)N3[C@](C(=O)O[C@H](\C(=C\[C@H]4C[C@@H](OC)[C@H](O)CC4)\C)[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(\C)/C[C@H](C)C[C@@H]2OC)(CCCC3)[H])[H].O
Synonyms:- (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-prop-2-en-1-yl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone hydrate
- 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, hydrate (1:1), (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
- 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
- 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
- 18-Tetramethyl-8-(2-Propenyl)-,Monohydrate,(3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*
- 3-(2-(4-Hydroxy-3-Methoxycyclohexyl)-1-Methylethenyl)-14,16-Dimethoxy-9,10,12,Monohydrate
- FK-506 Monohydrate
- Tacforius
- Tacrolimus hydrate
- Tacrolimushydrate
- Tsukubaenolide hydrate
- See more synonyms
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Found 14 products.
TACROLIMUS MONOHYDRATE CRS
CAS:TACROLIMUS MONOHYDRATE CRSFormula:C40H33N3O4Color and Shape:Added ModifiedMolecular weight:619.7077Tacrolimus
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C44H69NO12·H2OColor and Shape:White PowderMolecular weight:803.48198Tacrolimus monohydrate
CAS:Formula:C44H71NO13Purity:80%Color and Shape:SolidMolecular weight:822.0334Ref: IN-DA0035MN
1g258.00€5gTo inquire50gTo inquire100gTo inquire10mg36.00€25mg52.00€50mg66.00€100mg100.00€250mg149.00€FK-506 monohydrate
CAS:Formula:C44H69NO12·H2OPurity:≥ 98.0%Color and Shape:White to off-white solid or powderMolecular weight:822.03Tacrolimus Monohydrate
CAS:Formula:C44H69NO12·H2OPurity:>80.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:822.05Tacrolimus monohydrate
CAS:<p>Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FKBP to form a complex.</p>Formula:C44H71NO13Purity:97.07% - 98.05%Color and Shape:SolidMolecular weight:822.05Tacrolimus Hydrate
CAS:<p>Applications Tacrolimus Hydrate is a disease-modifying antirheumatic drugs (DMARDs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ogasawara, M., et al.: Mod. Rheumatol., 22, 831-836 (2012)<br></p>Formula:C44H69NO12·H2OColor and Shape:NeatMolecular weight:822.03Tacrolimus monohydrate
CAS:Anti-rheumatic; immunosuppressant; neuroprotective; neuroregenerativeFormula:C44H69NO12·H2OPurity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:822.03 g/molTacrolimus monohydrate - Bio-X ™
CAS:Tacrolimus is a calcineurin inhibitor drug that is used for the prevention of rejection after an organ transplant. This drug can also be used in the treatment of severe atopic dermatitis. Tacrolimus’ mechanism of action is not well known however it is understood that this drug inhibits T-lymphocyte activation by binding to an intracellular protein called FKBP-12. This drug also has anti-inflammatory properties.Formula:C44H69NO12·H2OPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:822.03 g/mol
