CAS 109683-61-6

Utibapril

Description:

Utibapril is an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. As a pharmaceutical compound, it works by inhibiting the activity of the ACE enzyme, which plays a crucial role in the renin-angiotensin-aldosterone system (RAAS). This inhibition leads to decreased production of angiotensin II, a potent vasoconstrictor, resulting in vasodilation, reduced blood pressure, and decreased workload on the heart. Utibapril is characterized by its ability to improve cardiovascular outcomes and is often prescribed in conjunction with other antihypertensive agents. Its pharmacokinetics include oral bioavailability, with metabolism primarily occurring in the liver. The compound is generally well-tolerated, though potential side effects may include cough, hyperkalemia, and renal impairment. As with other ACE inhibitors, it is contraindicated in pregnancy due to potential teratogenic effects. Overall, Utibapril represents a valuable option in the management of cardiovascular diseases, contributing to improved patient outcomes.

Formula: C₂₂H₃₁N₃O₅S

InChI: InChI=1/C22H31N3O5S/c1-6-30-20(29)16(13-12-15-10-8-7-9-11-15)23-14(2)17(26)25-18(19(27)28)31-21(24-25)22(3,4)5/h7-11,14,16,18,23H,6,12-13H2,1-5H3,(H,27,28)

SMILES: CCOC(=O)C(CCc1ccccc1)NC(C)C(=O)N1C(C(=O)O)SC(=N1)C(C)(C)C

Synonyms:

• Utibapril [INN:BAN]
• (S)-2-tert-Butyl-4-((S)-N-((S)-1-carboxy-3-phenylpropyl)alanyl)-delta(sup 2)-1,3,4-thiadiazoline-5-carboxylic acid, 4-ethyl ester
• Unii-87I5H747Bc
• Utibaprilo
• Utibaprilo [INN-Spanish]
• Utibaprilum
• Utibaprilum [INN-Latin]
• 1,3,4-Thiadiazole-2-carboxylic acid, 5-(1,1-dimethylethyl)-3-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-2,3-dihydro-, (2S-(2R*,3(R*(R*))))-
• 5-tert-butyl-3-[N-(1-ethoxy-1-oxo-4-phenylbutan-2-yl)alanyl]-2,3-dihydro-1,3,4-thiadiazole-2-carboxylic acid

Utibapril

CAS: 109683-61-6

Utibapril inhibits the activity of angiotensin-converting enzyme (ACE), an enzyme that breaks down the hormone angiotensin I. This leads to an increase in the levels of angiotensin II, which causes blood vessels to narrow by activating a G protein and stimulating the release of a second messenger, nitric oxide. Utibapril is used as a treatment for hypertension, congestive heart failure, and other cardiovascular disorders. It has been shown to cause insulin resistance in patients with type 2 diabetes mellitus and metabolic syndrome. The long-term use of utibapril may lead to congestive heart failure due to its effect on lipid metabolism.

Formula: C₂₂H₃₁N₃O₅S

Purity: Min. 95%

Molecular weight: 449.6 g/mol

Ref: 3D-JEA68361

Utibapril

CAS: 109683-61-6

Utibapril is an inhibitor of angiotensin-converting enzyme (ACE) with antihypertensive activities.

Formula: C₂₂H₃₁N₃O₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 449.56

Ref: TM-T13274