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CAS 109683-79-6

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Utibaprilat

Description:
Utibaprilat is a chemical compound classified as an angiotensin-converting enzyme (ACE) inhibitor, primarily used in the treatment of hypertension and heart failure. It is a potent and selective inhibitor that works by blocking the conversion of angiotensin I to angiotensin II, a peptide that causes blood vessels to constrict, thereby reducing blood pressure. The compound is characterized by its ability to enhance vasodilation and improve blood flow, contributing to its therapeutic effects. Utibaprilat is typically administered intravenously due to its pharmacokinetic properties, which include rapid onset of action and a relatively short half-life. Its structure includes a carboxylic acid group, which is essential for its biological activity. As with other ACE inhibitors, potential side effects may include hypotension, hyperkalemia, and renal impairment, necessitating careful monitoring during treatment. Overall, Utibaprilat represents a significant advancement in cardiovascular pharmacotherapy, providing an effective option for managing conditions related to elevated blood pressure.
Formula:C20H27N3O5S
InChI:InChI=1/C20H27N3O5S/c1-12(21-14(17(25)26)11-10-13-8-6-5-7-9-13)15(24)23-16(18(27)28)29-19(22-23)20(2,3)4/h5-9,12,14,16,21H,10-11H2,1-4H3,(H,25,26)(H,27,28)/t12-,14-,16-/m0/s1
Synonyms:
  • Utibaprilat [INN:BAN]
  • UNII-KN82541NHV
  • (S)-2-tert-Butyl-4-((S)-N-((S)-1-carboxy-3-phenylpropyl)alanyl-delta(sup 2)-1,3,4-thiadiazoline-5-carboxylic acid
  • (2S)-5-tert-butyl-3-{N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl}-2,3-dihydro-1,3,4-thiadiazole-2-carboxylic acid
  • FPL-63674
  • (2S)-5-tert-Butyl-3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]-2,3-dihydro-1,3,4-thiadiazole-2β-carboxylic acid
  • Utibaprirat
  • Utibaprilat
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