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CAS 1097733-15-7

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Fosdevirine

Description:
Fosdevirine is an antiretroviral medication primarily used in the treatment of HIV infection. It belongs to the class of non-nucleoside reverse transcriptase inhibitors (NNRTIs), which function by inhibiting the reverse transcriptase enzyme, thereby preventing the replication of the virus. The chemical structure of fosdevirine features a unique bicyclic core, contributing to its mechanism of action and pharmacological properties. It is characterized by its moderate lipophilicity, which influences its absorption and distribution in the body. Fosdevirine has shown a favorable pharmacokinetic profile, with a long half-life that allows for once-daily dosing, enhancing patient adherence to treatment regimens. Additionally, it has demonstrated efficacy against various HIV strains, including those resistant to other NNRTIs. Safety and tolerability profiles indicate that it may have fewer central nervous system side effects compared to some other agents in its class. Overall, fosdevirine represents a valuable option in the evolving landscape of HIV therapy, contributing to improved treatment outcomes for patients.
Formula:C20H17ClN3O3P
InChI:InChI=1S/C20H17ClN3O3P/c1-12-8-13(4-3-7-22)10-15(9-12)28(26,27-2)19-16-11-14(21)5-6-17(16)24-18(19)20(23)25/h3-6,8-11,24H,1-2H3,(H2,23,25)/b4-3+/t28-/m1/s1
InChI key:InChIKey=CGBYTKOSZYQOPV-ASSBYYIWSA-N
SMILES:P(OC)(=O)(C=1C=2C(NC1C(N)=O)=CC=C(Cl)C2)C3=CC(/C=C/C#N)=CC(C)=C3
Synonyms:
  • 1DX899
  • Fosdevirine
  • Phosphinic acid, P-[2-(aminocarbonyl)-5-chloro-1H-indol-3-yl]-P-[3-[(1E)-2-cyanoethenyl]-5-methylphenyl]-, methyl ester, [P(R)]-
  • IDX 899
  • GSK 2248761A
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