CAS 109806-71-5

2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethanol

Description:

2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethanol, with the CAS number 109806-71-5, is a chemical compound that belongs to the class of piperazine derivatives. This substance features a piperazine ring, which is a six-membered ring containing two nitrogen atoms, and is substituted with a phenylmethyl group and a 4-chlorophenyl moiety. The presence of the hydroxyl (-OH) group in the ethanol part of the molecule contributes to its potential solubility in polar solvents. This compound is often studied for its pharmacological properties, particularly in the context of neuropharmacology, as piperazine derivatives are known to exhibit various biological activities, including antipsychotic and anxiolytic effects. The chlorophenyl substitution may influence its interaction with biological targets, potentially enhancing its efficacy or altering its pharmacokinetic profile. Overall, the structural characteristics of this compound suggest it may have significant implications in medicinal chemistry and drug development.

Formula: C₁₉H₂₅Cl₃N₂O

InChI: InChI=1S/C19H23ClN2O/c20-18-8-6-17(7-9-18)19(16-4-2-1-3-5-16)22-12-10-21(11-13-22)14-15-23/h1-9,19,23H,10-15H2

InChI key: InChIKey=ZJQSBXXYLQGZBR-UHFFFAOYSA-N

SMILES: C(N1CCN(CCO)CC1)(C2=CC=C(Cl)C=C2)C3=CC=CC=C3

Synonyms:

• 1-Piperazineethanol, 4-(p-chloro-α-phenylbenzyl)-
• 1-Piperazineethanol, 4-[(4-chlorophenyl)phenylmethyl]-
• 2-[4-{4-Chlorophenyl} Phenylmethyl]-1-Piperazinylethanol
• 2-{4-[(4-CHLORO-PHENYL)-PHENYL-METHYL]-piperazin-1-YL}-ETHANOL
• 2-{4-[(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}ethanol
• 4-[(4-Chlorophenyl)phenylmethyl]-1-piperazine
• 4-[(4-Chlorophenyl)phenylmethyl]-1-piperazineethanol
• Cetirizine ethanol
• Cetirizine impurity G
• Unii-Pgv947X9B1
• 2-[4-[(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethanol
• Cetirizine Impurity 15 Monomer （Cetirizine EP Impurity G Monomer ）
• 4-[(4-Chlorophenyl)phenylMethyl]-(4-hydroxy-1-piperidinyl)-1-butanone
• 2-[4-{Chlorophenyl}Phenylmethyl]-1-
• Levocetirizine Impurity G
• 4-(p-Chloro-α-phenylbenzyl)-1-piperazineethanol
• Cetirizine -EP-Imp-G
• Levocetirizine Impurity 6
• Cetirizine EP Impurity G Hydrochloride

Cetirizine EP Impurity G (Cetirizine USP Related Compound G (Free Form), Levocetirizine EP Impurity H)

CAS: 109806-71-5

Formula: C₁₉H₂₃ClN₂O

Color and Shape: Pale Yellow Semi-Solid (Low M P )

Molecular weight: 330.86

Ref: 4Z-C-2012

4-(p-Chloro-α-phenylbenzyl)-1-piperazineethanol

CAS: 109806-71-5

Stability Very Hygroscopic
Applications 4-(p-Chloro-α-phenylbenzyl)-1-piperazineethanol is used in the synthesis of antifungal triazole and imidazole derivatives. Impurity of an intermediate in the formation of Cetrizine.
References Rezaei, Z. et al.: Archiv. Pharm., 344, 658 (2011)

Formula: C₁₉H₂₃ClN₂O

Color and Shape: White To Off-White

Molecular weight: 330.85

Ref: TR-C377565

2-[4-[(4-CHLOROPHENYL)-PHENYLMETHYL]PIPERAZIN-1-YL]ETHANOL

CAS: 109806-71-5

Formula: C₁₉H₂₅Cl₃N₂O

Purity: 95.0%

Molecular weight: 403.77

Ref: 10-F540017

4-(p-Chloro-α-phenylbenzyl)-1-piperazineethanol-d4

Controlled Product

CAS: 109806-71-5

Formula: C₁₉H₁₉D₄ClN₂O

Color and Shape: Neat

Molecular weight: 334.88

Ref: TR-C377567

4-[(4-Chlorophenyl)phenylmethyl]-1-piperazineethanol dihydrochloride

CAS: 109806-71-5

4-[(4-Chlorophenyl)phenylmethyl]-1-piperazineethanol dihydrochloride is a cholinergic drug that is used to treat allergic rhinitis in children and adults. It has been shown to be well tolerated in pediatric patients and geriatric patients, as well as being an innovative, labile, and biopharmaceutical compound. 4-[(4-Chlorophenyl)phenylmethyl]-1-piperazineethanol dihydrochloride is not metabolized by the liver and does not have significant side effects. It has a low potential for abuse because of its low solubility in water. It is an antihistamine that blocks the action of histamine at H1 receptors on smooth muscle cells in the nose, which helps reduce nasal congestion and sneezing.

Formula: C₁₉H₂₃ClN₂O·2HCl

Purity: Min. 95%

Molecular weight: 403.77 g/mol

Ref: 3D-FC53582