CAS 109889-09-0

Granisetron

Description:

Granisetron is a selective serotonin 5-HT3 receptor antagonist primarily used as an antiemetic to prevent nausea and vomiting associated with chemotherapy, radiation therapy, and surgery. It is a white to off-white crystalline powder that is soluble in water and exhibits a pKa value indicative of its weakly basic nature. Granisetron has a molecular formula that reflects its complex structure, which includes a piperidine ring and a carbonyl group, contributing to its pharmacological activity. The substance is typically administered orally or intravenously, and its pharmacokinetics demonstrate a relatively long half-life, allowing for effective management of emesis. Granisetron is well-tolerated, with a side effect profile that may include headache, constipation, and dizziness. Its efficacy in blocking serotonin receptors in the central nervous system makes it a valuable therapeutic agent in oncology and postoperative care. As with all medications, it is essential to consider potential drug interactions and contraindications when prescribing granisetron.

Formula: C₁₈H₂₄N₄O

InChI: InChI=1/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12-,13+,14-

InChI key: InChIKey=MFWNKCLOYSRHCJ-BTTYYORXNA-N

SMILES: C(N[C@H]1C[C@@]2(N(C)[C@](C1)(CCC2)[H])[H])(=O)C=3C=4C(N(C)N3)=CC=CC4

Synonyms:

• 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide
• 1H-Indazole-3-carboxamide, 1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-, endo-
• 1H-Indazole-3-carboxamide, 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-
• 9-Azabicyclo[3.3.1]nonane, 1H-indazole-3-carboxamide deriv.
• Apf 530
• Brl 43694
• Brl 43964
• Granisetron free base
• Kevatril
• Sancuso
• Sustol
• endo-Granisetron

Granisetron

CAS: 109889-09-0

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₁₈H₂₄N₄O

Color and Shape: Off-White Light Yellow Powder

Molecular weight: 312.19501

Ref: 45-1298092

1-methyl-N-[(1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-1H-indazole-3-carboxamide

CAS: 109889-09-0

Formula: C₁₈H₂₄N₄O

Purity: 98%

Color and Shape: Solid

Molecular weight: 312.4094

Ref: IN-DA007EID

Granisetron

CAS: 109889-09-0

Formula: C₁₈H₂₄N₄O

Molecular weight: 312.42

Ref: 4Z-G-0725

Granisetron Hydrochloride

CAS: 107007-99-8, 109889-09-0

Formula: C₁₈H₂₄N₄O·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 348.88

Ref: 3B-G0401

Granisetron

CAS: 109889-09-0

Granisetron, a serotonin receptor (5HT-3 selective) antagonist, is used as an antinauseant and antiemetic for cancer chemotherapy.

Formula: C₁₈H₂₄N₄O

Color and Shape: Solid

Molecular weight: 312.41

Ref: TM-T22340

1-Methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-indazole-3-carboxamide

Controlled Product

CAS: 109889-09-0

1-Methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-indazole-3-carboxamide is a chemical inhibitor of the 5HT2 receptor, which is responsible for regulating nausea and vomiting. It has been shown to have antiemetic properties, and can be used in chemotherapy to control nausea and vomiting. The 5HT2 receptor is coupled to Gs proteins and inhibits adenylyl cyclase activity, while 1MMAI binds to the 5HT2A receptor and blocks serotonin from binding. This prevents serotonin from activating Gq protein receptors, which are involved in the generation of intracellular calcium concentrations that lead to neurotransmitter release. 1MMAI also inhibits the activation of phospholipase C by serotonin, resulting in decreased levels of diacylglycerol (DAG) and inositol triphosphate (IP3). These changes inhibit plate

Formula: C₁₈H₂₄N₄O

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 312.41 g/mol

Ref: 3D-FM137557

Granisetron

Controlled Product

CAS: 109889-09-0

Applications Granisetron is a selective 5HT-3 antagonist.

Formula: C₁₈H₂₄N₄O

Color and Shape: Neat

Molecular weight: 312.41

Ref: TR-G780013