CAS 109971-63-3

Combretastatin A1

Description:

Combretastatin A1 is a naturally occurring compound derived from the bark of the Combretum caffrum tree, known for its potent anti-cancer properties. It belongs to a class of compounds called stilbenes and is characterized by its ability to inhibit tubulin polymerization, which disrupts the formation of microtubules necessary for cell division. This mechanism makes it a promising candidate for cancer therapy, particularly in targeting solid tumors. Combretastatin A1 is typically found as a white to off-white solid and is soluble in organic solvents like dimethyl sulfoxide (DMSO) but has limited solubility in water. Its chemical structure features a trans-stilbene configuration, which is crucial for its biological activity. Additionally, the compound has been studied for its potential to enhance the efficacy of other chemotherapeutic agents and its ability to induce tumor vascular collapse, leading to reduced blood supply to tumors. Ongoing research continues to explore its therapeutic applications and optimize its delivery in clinical settings.

Formula: C₁₈H₂₀O₆

InChI: InChI=1S/C18H20O6/c1-21-13-8-7-12(16(19)17(13)20)6-5-11-9-14(22-2)18(24-4)15(10-11)23-3/h5-10,19-20H,1-4H3/b6-5-

InChI key: InChIKey=YUSYSJSHVJULID-WAYWQWQTSA-N

SMILES: O(C)C1=C(OC)C=C(/C=C\C2=C(O)C(O)=C(OC)C=C2)C=C1OC

Synonyms:

• (Z)-3-Methoxy-6-(3,4,5-Trimethoxystyryl)Benzene-1,2-Diol
• 1,2-Benzenediol, 3-methoxy-6-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-
• 1,2-Benzenediol, 3-methoxy-6-[2-(3,4,5-trimethoxyphenyl)ethenyl]-, (Z)-
• 3-Methoxy-6-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-1,2-benzenediol
• 3-methoxy-6-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]benzene-1,2-diol
• 3-methoxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]benzene-1,2-diol
• Combretastatin A1( 3-Methoxy-6-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-benzene-1,2-diol )
• Combretastatin A₁
• OXi 4500
• Combretastatin A1

Combretastatin A1

CAS: 109971-63-3

Formula: C₁₈H₂₀O₆

Purity: 95%

Molecular weight: 332.3478

Ref: IN-DA00JRNZ

Combretastatin A-1

CAS: 109971-63-3

Combretastatin A-1

Purity: ≥95%

Molecular weight: 332.35g/mol

Ref: 54-BUP21675

Combretastatin A-1

CAS: 109971-63-3

Combretastatin A-1 is a microtubule inhibitor with anti-tumour and can be used to study liver cancer.

Formula: C₁₈H₂₀O₆

Purity: 97.49% - 97.49%

Color and Shape: Solid

Molecular weight: 332.35

Ref: TM-T36848

Combretastatin A1

CAS: 109971-63-3

Combretastatin A1 is a natural product derived from the bark of the Combretum species. It has been shown to be effective against metastatic colorectal cancer cells and has been used in biological studies to evaluate the cytotoxicity of pyrazole derivatives. Combretastatin A1 is hydroxylated by cytochrome P450 enzymes, which converts it into a reactive form. This reactive form can then generate DNA adducts that lead to cell death. Combretastatin A1 also binds to the femoral vein, resulting in significant cytotoxicity in vivo.

Formula: C₁₈H₂₀O₆

Purity: Min. 95%

Molecular weight: 332.3 g/mol

Ref: 3D-JEA97163