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N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)

CAS 110025-28-0: N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)

Description:N-Desmethyl-4-hydroxy Tamoxifen, with the CAS number 110025-28-0, is a derivative of the selective estrogen receptor modulator (SERM) Tamoxifen, which is primarily used in the treatment of estrogen receptor-positive breast cancer. This compound is characterized by the absence of a methyl group at the nitrogen atom and the presence of a hydroxyl group at the para position of the phenyl ring, which enhances its estrogenic and anti-estrogenic activities. The compound exists as an approximate 1:1 mixture of E (trans) and Z (cis) isomers, which can influence its biological activity and pharmacokinetics. N-Desmethyl-4-hydroxy Tamoxifen exhibits a significant affinity for estrogen receptors, contributing to its role in modulating estrogenic effects in target tissues. Its solubility and stability can vary based on the pH and solvent conditions, making it important for formulation in pharmaceutical applications. Overall, this compound plays a crucial role in cancer therapy and research related to estrogen signaling pathways.

Formula:C25H27NO2

InChI:InChI=1/C25H27NO2/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2/h4-16,26-27H,3,17-18H2,1-2H3/b25-24+

  • Synonyms:
  • 4-[1-[4-[2-(Methylamino)Ethoxy]Phenyl]-2-Phenyl-1-Butenyl]Phenol
  • 4OHNDtam
  • E/Z Endoxifen
  • 4-hydroxy-N-desmethyltamoxifen
  • 4-[(E)-1-[4-(2-methylaminoethoxy)phenyl]-2-phenyl-but-1-enyl]phenol
  • 4-[(1E)-1-{4-[2-(methylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol
  • N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)
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Found 5 products.

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Ref: 4Z-T-017

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Estimated delivery in United States, on Monday 3 Mar 2025
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Ref: 4Z-T-0113

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100mgTo inquire
Estimated delivery in United States, on Monday 3 Mar 2025
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Endoxifen

CAS:110025-28-0

Ref: TM-T4281

5mg48.00 €
10mg71.00 €
50mg220.00 €
1mL*10mM (DMSO)90.00 €
Estimated delivery in United States, on Tuesday 11 Mar 2025
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N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)

Controlled Product
CAS:110025-28-0

Ref: TR-D292043

5mg278.00 €
10mg452.00 €
25mg945.00 €
Estimated delivery in United States, on Wednesday 12 Mar 2025
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(E/Z)-Endoxifen

CAS:110025-28-0

Ref: 3D-FE15969

5mg348.00 €
10mg484.00 €
25mg953.00 €
Estimated delivery in United States, on Tuesday 15 Apr 2025
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