CAS 110078-46-1

PLERIXAFOR

Description:

Plerixafor, with the CAS number 110078-46-1, is a small molecule that functions as a chemokine receptor antagonist, specifically targeting the CXCR4 receptor. It is primarily used in the context of hematopoietic stem cell mobilization for patients undergoing stem cell transplantation. Plerixafor works by blocking the interaction between the CXCR4 receptor and its ligand, stromal-derived factor-1 (SDF-1), which is crucial for the retention of stem cells in the bone marrow. This action facilitates the mobilization of stem cells into the bloodstream, making them more accessible for collection. The substance is typically administered via subcutaneous injection and has a relatively short half-life, necessitating careful timing in relation to stem cell collection procedures. Plerixafor is generally well-tolerated, though it may cause side effects such as injection site reactions, nausea, and diarrhea. Its development has significantly improved the efficiency of stem cell harvesting, particularly in patients with certain hematological malignancies.

Formula: C₂₈H₅₄N₈

InChI: InChI=1/C28H54N8.8BrH.2H2O/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H;2*1H2

InChI key: InChIKey=YIQPUIGJQJDJOS-UHFFFAOYSA-N

SMILES: C(C1=CC=C(CN2CCCNCCNCCCNCC2)C=C1)N3CCCNCCNCCCNCC3

Synonyms:

• 1,1'-(Benzene-1,4-Diyldimethanediyl)Bis(1,4,8,11-Tetraazacyclotetradecane)
• 1,1'-(Benzene-1,4-Diyldimethanediyl)Bis-1,4,8,11-Tetraazacyclotetradecane Octahydrobromide Dihydrate
• 1,1'-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane
• 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane]Octahydrobromide Dihydrate
• 1,1′-Xylyl bis-1.4,8,11 tetraaza cyclotetradecane
• 1,4,8,11-Tetraazacyclotetradecane, 1,1′-[1,4-phenylenebis(methylene)]bis-
• 1,4-Bis((1,4,8,11-Tetraazacyclotetradecan-1-Yl)Methyl)Benzene
• 1-[[4-(1,4,8,11-Tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane
• Amd 3100
• Jkl 169
• Jm 3100
• Mozobil
• Sdz Sid 791
• Plerixafor
• Plerixafor(AMD3100)
• Plerixafor/JM3100/AMD3100
• plerixafor, AMD 3100, AMD-3100, AMD3100, JLK 169, Mozobil, 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylMethyl)phenyl] Methyl]-1,4,8,11-tetrazacyclotetradecane
• AMD310
• 1-{[4-(1,4,8,11-tetraazacyclotetradecan-1-ylMethyl)phenyl]Methyl}-1,4,8,11-tetraazacyclotetradecane
• AMD3100 (Plerixafor)
• Unii-S915p5499n

Plerixafor

CAS: 110078-46-1

Drugs with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

Formula: C₂₈H₅₄N₈

Color and Shape: White Off-White Powder

Molecular weight: 502.44714

Ref: 45-1545135

1-{[4-(1,4,8,11-tetraazacyclotetradecan-1-ylmethyl)phenyl]methyl}-1,4,8,11-tetraazacyclotetradecane

CAS: 110078-46-1

Formula: C₂₈H₅₄N₈

Purity: 99%

Color and Shape: Solid

Molecular weight: 502.7820

Ref: IN-DA007VXT

Plerixafor

CAS: 110078-46-1

Plerixafor

Purity: ≥95%

Molecular weight: 502.78g/mol

Ref: 54-BUP13173

Plerixafor

CAS: 110078-46-1

Plerixafor

Purity: 98%

Molecular weight: 502.78g/mol

Ref: 54-OR1025718

Plerixafor

CAS: 110078-46-1

Formula: C₂₈H₅₄N₈

Purity: >98.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 502.80

Ref: 3B-P2678

Plerixafor

CAS: 110078-46-1

Color and Shape: Neat

Ref: 86-MM3938.00

Plerixafor

CAS: 110078-46-1

Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.

Formula: C₂₈H₅₄N₈

Purity: 99.17% - >99.99%

Color and Shape: Solid

Molecular weight: 502.78

Ref: TM-T1776

Plerixafor-d4

CAS: 110078-46-1

Formula: C₂₈H₅₀N₈D₄

Molecular weight: 506.82

Ref: 4Z-P-552

Plerixafor

CAS: 110078-46-1

Formula: C₂₈H₅₄N₈

Purity: ≥ 98.0%

Color and Shape: White powder

Molecular weight: 502.78

Ref: 7W-GP0472

Plerixafor Impurity 24

CAS: 110078-46-1

Formula: C₁₈H₃₀N₄O₂

Molecular weight: 334.46

Ref: 4Z-P-5528

Plerixafor

CAS: 110078-46-1

Stability Hygroscopic
Applications Plerixafor is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM). Selective CXCR4 antagonist.
References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),

Formula: C₂₈H₅₄N₈

Color and Shape: Off White Powder

Molecular weight: 502.78

Ref: TR-P580500

Plerixafor

CAS: 110078-46-1

Initially identified as a selective inhibitor of HIV-1 and HIV-2 replication. This activity was ascribed to the specific binding to chemokine receptor CXCR4 and inhibition of its signaling downstream, mediated by SDF-1. Antagonizes binding of CXCL12 to CXCR4, inducing mobilization of hematopoietic progenitor cells that is enhanced in synergy with G-CSF.

Formula: C₂₈H₅₄N₈

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 502.78 g/mol

Ref: 3D-FP36846

1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene

CAS: 110078-46-1

Formula: C₂₈H₅₄N₈

Purity: 95+%

Color and Shape: Solid

Molecular weight: 502.796

Ref: 10-F362020