CAS 110104-37-5

N-Acetylacyclovir

Description:

N-Acetylacyclovir is an antiviral compound derived from acyclovir, primarily used in the treatment of herpes simplex virus infections. It is characterized by its structural modification, which includes an acetyl group that enhances its solubility and bioavailability compared to acyclovir. The substance exhibits a mechanism of action similar to that of acyclovir, functioning as a nucleoside analog that inhibits viral DNA synthesis. N-Acetylacyclovir is typically administered orally and is known for its improved pharmacokinetic properties, allowing for more effective therapeutic outcomes. The compound is generally well-tolerated, with a safety profile similar to that of acyclovir, although potential side effects may include gastrointestinal disturbances and allergic reactions. Its chemical formula reflects the presence of carbon, hydrogen, nitrogen, and oxygen atoms, contributing to its stability and efficacy as an antiviral agent. Overall, N-Acetylacyclovir represents a significant advancement in antiviral therapy, particularly for patients with recurrent herpes infections.

Formula: C₁₀H₁₃N₅O₄

InChI: InChI=1S/C10H13N5O4/c1-6(17)12-10-13-8-7(9(18)14-10)11-4-15(8)5-19-3-2-16/h4,16H,2-3,5H2,1H3,(H2,12,13,14,17,18)

InChI key: InChIKey=DJMINGJGFGSDDB-UHFFFAOYSA-N

SMILES: C(OCCO)N1C2=C(C(=O)N=C(NC(C)=O)N2)N=C1

Synonyms:

• 9-[(2-Hydroxyethoxy)methyl]-N²-acetylguanine
• N-Acetylacyclovir
• N-[6,9-Dihydro-9-[(2-hydroxyethoxy)methyl]-6-oxo-1H-purin-2-yl]acetamide
• N-{9-[(2-Hydroxyethoxy)methyl]-6-oxo-6,9-dihydro-1H-purin-2-yl}acetamide
• N-{9-[(2-hydroxyethoxy)methyl]-6-oxo-6,9-dihydro-3H-purin-2-yl}acetamide
• N²-Acetylaciclovir
• T56 Bn Dn Fn Hnj D1O2Q Gmv1 Iq [Wln]
• T56 Bn Dn Fvm Inj B1O2Q Hmv1 [Wln]
• acetamide, N-[6,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6-oxo-1H-purin-2-yl]-
• 9-[(2-Hydroxyethoxy)methyl]-N2-acetylguanine
• N2-Acetylaciclovir

Acyclovir Related Compound F (N-[9-[(2-Hydroxyethoxy)methyl]-6-oxo-6,9-dihydro-1H-purin-2-yl]acetamide)

CAS: 110104-37-5

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Formula: C₁₀H₁₃N₅O₄

Color and Shape: White Yellow Crystalline Powder

Molecular weight: 267.24

Ref: 45-1012054

N2-Acetyl-9-[(2'-hydroxyethoxy)methyl]guanine

CAS: 110104-37-5

Formula: C₁₀H₁₃N₅O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 267.2413

Ref: IN-DA008SHJ

N2-Acetylaciclovir

CAS: 110104-37-5

N2-Acetylaciclovir (Aciclovir EP Impurity F) is a derivative of the antiviral compound Aciclovir, which has selective T-cell immunotoxicity.

Formula: C₁₀H₁₃N₅O₄

Purity: 98.2%

Color and Shape: Solid

Molecular weight: 267.24

Ref: TM-T21113

N2-Acetylaciclovir

CAS: 110104-37-5

N2-Acetylaciclovir

Purity: ≥98%

Molecular weight: 267.24g/mol

Ref: 54-BUP02313

Aciclovir (Acyclovir) EP Impurity F (Acyclovir USP Related Compound F)

CAS: 110104-37-5

Formula: C₁₀H₁₃N₅O₄

Color and Shape: Off-White Solid

Molecular weight: 267.25

Ref: 4Z-A-048

N-[9-[(2-Hydroxyethoxy)-methyl]-6-oxo-6,9-dihydro-1H-purin-2-yl]acetamide

Controlled Product

CAS: 110104-37-5

Formula: C₁₀H₁₃N₅O₄

Color and Shape: Neat

Molecular weight: 267.24

Ref: 86-MM0061.06

N2-Acetyl Acyclovir

Controlled Product

CAS: 110104-37-5

Impurity Aciclovir EP Impurity F
Applications N2-Acetyl Acyclovir (Aciclovir EP Impurity F) is an impurity of Acyclovir (A192400).
References Balon, K., et al.: Pharm. Res., 16, 882 (1999),

Formula: C₁₀H₁₃N₅O₄

Color and Shape: Beige

Molecular weight: 267.24

Ref: TR-A168015

N2-Acetyl acyclovir

CAS: 110104-37-5

Purity: 98%

Molecular weight: 267.245

Ref: 10-F988130

N2-Acetyl Acyclovir-d4

Controlled Product

CAS: 110104-37-5

Applications N2-Acetyl Acyclovir-d4 is the isotope labelled analog of N2-Acetyl Acyclovir (A168015); an impurity of Acyclovir (A192400) which is an orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Also an antiviral.
References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992)

Formula: C₁₀H₉D₄N₅O₄

Color and Shape: Neat

Molecular weight: 271.27

Ref: TR-A168017

Aciclovir EP Impurity F

CAS: 110104-37-5

Formula: C₁₀H₁₃N₅O₄

Molecular weight: 267.24

Ref: ST-EA-CP-A8006