Donepezil hydrochloride is a reversible inhibitor of the enzyme acetylcholinesterase, primarily used in the treatment of Alzheimer's disease to enhance cognitive function. It is a white to off-white crystalline powder that is soluble in water and exhibits a pH range of approximately 4.5 to 6.5 in solution. The molecular formula of donepezil hydrochloride is C24H29NO3·HCl, indicating the presence of a tertiary amine, which contributes to its pharmacological activity. The compound has a relatively high molecular weight and is characterized by its ability to cross the blood-brain barrier, allowing it to exert its effects on central nervous system neurotransmission. Donepezil is typically administered orally and has a half-life that supports once-daily dosing, making it convenient for patients. Common side effects may include gastrointestinal disturbances, insomnia, and muscle cramps. Overall, donepezil hydrochloride plays a significant role in managing symptoms of dementia associated with Alzheimer's disease, improving the quality of life for affected individuals.

Donepezil hydrochloride, marketed under the trade name Aricept, is a piperidine-type reversible cholinesterase (ChE) inhibitor, known chemically as (±)-2, 3-dihydro-5, 6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1Hinden- 1-one hydrochloride. It has an empirical formula of C24H29NO3HCl and a molecular weight of 415.96. Donepezil hydrochloride is a white crystalline powder and is freely soluble in chloroform, soluble in water and in glacial acetic acid, slightly soluble in ethanol and in acetonitrile, and practically insoluble in ethyl acetate and in n-hexane. It can bind and reversibly inactivate the cholinesterases, thus inhibiting hydrolysis of acetylcholine. This results in an increased acetylcholine concentration at cholinergic synapses. As for the above function, donepezil hydrochloride can be used for the treatment of symptoms for people with mild-to-severe Alzheimer's disease, but it can’t slow the progression of or cure the disease.

Donepezil hydrochloride

110119-84-1: Donepezil hydrochloride is a reversible inhibitor of the enzyme acetylcholinesterase, primarily used in the treatment of Alzheimer's disease to enhance cognitive function. It is a white to off-white crystalline powder that is soluble in water and exhibits a pH range of approximately 4.5 to 6.5 in solution. The molecular formula of donepezil hydrochloride is C24H29NO3·HCl, indicating the presence of a tertiary amine, which contributes to its pharmacological activity. The compound has a relatively high molecular weight and is characterized by its ability to cross the blood-brain barrier, allowing it to exert its effects on central nervous system neurotransmission. Donepezil is typically administered orally and has a half-life that supports once-daily dosing, making it convenient for patients. Common side effects may include gastrointestinal disturbances, insomnia, and muscle cramps. Overall, donepezil hydrochloride plays a significant role in managing symptoms of dementia associated with Alzheimer's disease, improving the quality of life for affected individuals.

CAS 110119-84-1

Donepezil hydrochloride

Donepezil Hydrochloride

Ref: 54-OR1029881