CAS 110143-09-4

9-(2,3-Dideoxy-3-fluoro-β-D-threo-pentofuranosyl)-9H-purin-6-amine

Description:

9-(2,3-Dideoxy-3-fluoro-β-D-threo-pentofuranosyl)-9H-purin-6-amine, with CAS number 110143-09-4, is a nucleoside analog that features a purine base linked to a modified sugar moiety. This compound is characterized by the presence of a 2,3-dideoxy-3-fluoro-β-D-threo-pentofuranosyl group, which alters its biological activity compared to natural nucleosides. The fluorine substitution at the 3-position of the sugar enhances its stability and can influence its interaction with nucleic acid synthesis enzymes. As a purine derivative, it can potentially act as an antiviral or anticancer agent by interfering with nucleic acid metabolism. The structural modifications contribute to its unique pharmacological properties, making it a subject of interest in medicinal chemistry and drug development. Its solubility, stability, and bioavailability are critical factors that determine its efficacy in therapeutic applications. Overall, this compound exemplifies the strategic design of nucleoside analogs for targeted biological activity.

Formula: C₁₀H₁₂FN₅O₂

InChI: InChI=1S/C10H12FN5O2/c11-5-1-7(18-6(5)2-17)16-4-15-8-9(12)13-3-14-10(8)16/h3-7,17H,1-2H2,(H2,12,13,14)/t5-,6-,7-/m1/s1

InChI key: InChIKey=CTDUJDNZPPZTAV-FSDSQADBSA-N

SMILES: NC1=C2C(N(C=N2)[C@@H]3O[C@H](CO)[C@H](F)C3)=NC=N1

Synonyms:

• 2',3'-Dideoxy-2'-fluoro-ara-A
• 2',3'-Dideoxy-2'-fluoro-beta-D-arabinofuranosyladenine
• 2',3'-Dideoxy-3'-Fluoroadenosine
• 2'-Fluoro-2',3'-dideoxyarabinosyl adenine
• 9-(2,3-Dideoxy-3-fluoro-β-<span class="text-smallcaps">D</span>-threo-pentofuranosyl)-9H-purin-6-amine
• 9H-Purin-6-amine, 9-(2,3-dideoxy-3-fluoro-beta-D-threo-pentofuranosyl)-
• 9H-Purin-6-amine, 9-(2,3-dideoxy-3-fluoro-β-<span class="text-smallcaps">D</span>-threo-pentofuranosyl)-
• Ddf-ara-A
• 9H-Purin-6-amine, 9-(2,3-dideoxy-3-fluoro-β-D-threo-pentofuranosyl)-
• 9-(2,3-Dideoxy-3-fluoro-β-D-threo-pentofuranosyl)-9H-purin-6-amine
• 2',3'-Dideoxy-2'-fluoroarabinofuranosyladenine