CAS 11018-89-6

Card-20(22)-enolide, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-, hydrate (1:8), (1β,3β,5β,11α)-

Description:

Card-20(22)-enolide, specifically identified by its CAS number 11018-89-6, is a complex organic compound belonging to the class of cardenolides, which are steroidal glycosides. This substance features a steroid backbone with multiple hydroxyl groups, contributing to its hydrophilic properties. The presence of a sugar moiety, specifically a 6-deoxy-α-L-mannopyranosyl group, enhances its solubility in water and influences its biological activity. The compound is characterized by its specific stereochemistry, denoted by the (1β,3β,5β,11α) configuration, which is crucial for its interaction with biological targets, particularly in the context of cardiac glycosides. Card-20(22)-enolide is typically found in a hydrated form, indicating the presence of water molecules in its crystalline structure, which can affect its stability and solubility. This compound is of interest in pharmacology due to its potential therapeutic effects, particularly in the treatment of heart conditions, as it may influence cardiac contractility and rhythm.

Formula: C₂₉H₄₄O₁₂·8H₂O

InChI: InChI=1S/C29H44O12.8H2O/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31;;;;;;;;/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3;8*1H2/t13-,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28+,29-;;;;;;;;/m0......../s1

InChI key: InChIKey=TYBARJRCFHUHSN-DMJRSANLSA-N

SMILES: C(O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(C[C@H]3O)[C@H](CC4)C=5COC(=O)C5)(CC[C@]1(O)C[C@@H](O[C@H]6[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O6)C[C@H]2O)[H])[H].O

Synonyms:

• (1beta,3beta,5beta,11alpha)-3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxycard-20(22)-enolide
• (1beta,3beta,5beta,8xi,9xi,11alpha)-3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxycard-20(22)-enolide
• Card-20(22)-enolide, 3-[(6-deoxy-α-<span class="text-smallcaps">L</span>-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-, hydrate (1:8), (1β,3β,5β,11α)-
• Card-20(22)-enolide, 3-[(6-deoxy-α-<span class="text-smallcaps">L</span>-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-, octahydrate, (1β,3β,5β,11α)-
• G-Strophantin octahydrate
• Strophantine octahydrate
• Card-20(22)-enolide, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-, octahydrate, (1β,3β,5β,11α)-
• Ouabain octahydrate
• Card-20(22)-enolide, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-, hydrate (1:8), (1β,3β,5β,11α)-

Ouabain octahydrate, 95%

CAS: 11018-89-6

Inhibitor of sodium-potassium-dependent ATPase

Formula: C₂₉H₆₀O₂₀

Purity: 95%

Color and Shape: White to off-white to pale yellow, Powder

Molecular weight: 728.78

Ref: 02-J60724

OUABAIN CRS

CAS: 11018-89-6

OUABAIN CRS

Formula: C₂₉H₄₄O₁₂

Color and Shape: Powder

Molecular weight: 584.6525

Ref: 41-O0200000

Ouabain octahydrate

CAS: 11018-89-6

Ouabain octahydrate (Acocantherine) is a cardiac glycoside that inhibits Na(+)/K(+) ATPase. Ouabain octahydrate regulates transcription of MDR (increase, Pgp) and MRP (increase MRP1 and decrease CFTR, cyctic fibrosis transport receptor or cAMP-activated Cl- channel) genes, also alters localization of MRP1.

Formula: C₂₉H₄₄O₁₂·8H₂O

Purity: 98% - 99.90%

Color and Shape: Solid

Molecular weight: 728.77

Ref: TM-T1318

Ouabain octahydrate, 95%

CAS: 11018-89-6

Formula: C₂₉H₄₄O₁₂·8H₂O

Purity: ≥ 95.0%

Color and Shape: White or off-white powder

Molecular weight: 728.78

Ref: 7W-GC9310

Ouabain octahydrate

CAS: 11018-89-6

Ouabain octahydrate

Purity: ≥98%

Molecular weight: 728.77g/mol

Ref: 54-BUP11681

Ouabain octahydrate, EP grade

CAS: 11018-89-6

Formula: C₂₉H₄₄O₁₂·8H₂O

Purity: ≥ 96.0%

Color and Shape: A white or almost white, crystalline powder or colourless crystals

Molecular weight: 728.78

Ref: 7W-GC9218

Ouabain Octahydrate

Controlled Product

CAS: 11018-89-6

Formula: C₂₉H₄₄O₁₂H₂O

Color and Shape: Neat

Molecular weight: 728.77

Ref: 86-MM1665.00

Ouabain Octahydrate

Controlled Product

CAS: 11018-89-6

Applications A cardiac glycoside that inhibits Na(+)/K(+) ATPase. It regulates transcription of MDR (increase, Pgp) and MRP (increase MRP1 and decrease CFTR, cyctic fibrosis transport receptor or cAMP-activated Cl- channel) genes, also alters localization of MRP1.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Padilha, A.S. et al.: Clin. Exp. Pharmacol. Physiol., 35, 801 (2008); Blaustein, M.P. et al.: Clin. Exp. Hypertens. 20, 691 (1998); van Huysse, J.W. et al.: Clin. Exp. Hypertens. 20, 657 (1998);

Formula: C₂₉H₄₄O₁₂·8H₂O

Color and Shape: White To Off-White

Molecular weight: 728.77

Ref: TR-O714500

Ouabain octahydrate

CAS: 11018-89-6

Na+/K+-ATPase inhibitor

Formula: C₂₉H₄₄O₁₂·8H₂O

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 728.77 g/mol

Ref: 3D-MO16828