CAS 1101854-58-3

1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 4-nitrophenyl ester

Description:

1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 4-nitrophenyl ester, identified by CAS number 1101854-58-3, is a complex organic compound characterized by its piperidine ring structure, which contributes to its potential biological activity. The presence of the bis(1,3-benzodioxol-5-yl)hydroxymethyl group indicates that it may exhibit interesting interactions due to the dioxole moieties, which are known for their electron-rich properties. The 4-nitrophenyl ester functionality suggests that the compound may possess significant reactivity, particularly in nucleophilic substitution reactions. This compound may also exhibit various pharmacological properties, making it of interest in medicinal chemistry. Its solubility, stability, and reactivity can be influenced by the functional groups present, which may affect its application in drug development or as a biochemical probe. Overall, the unique structural features of this compound suggest potential utility in various chemical and biological contexts, warranting further investigation into its properties and applications.

Formula: C₂₇H₂₄N₂O₉

InChI: InChI=1S/C27H24N2O9/c30-26(38-21-5-3-20(4-6-21)29(32)33)28-11-9-17(10-12-28)27(31,18-1-7-22-24(13-18)36-15-34-22)19-2-8-23-25(14-19)37-16-35-23/h1-8,13-14,17,31H,9-12,15-16H2

InChI key: InChIKey=SEGYOKHGGFKMCX-UHFFFAOYSA-N

SMILES: C(O)(C=1C=C2C(=CC1)OCO2)(C=3C=C4C(=CC3)OCO4)C5CCN(C(OC6=CC=C(N(=O)=O)C=C6)=O)CC5

Synonyms:

• JZL 184
• 1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 4-nitrophenyl ester
• 4-Nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)Methyl]-1-piperidinecarboxylate
• 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester
• 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester JZL 184

4-Nitrophenyl4-(Bis(Benzo[D][1,3]Dioxol-5-Yl)(Hydroxy)Methyl)Piperidine-1-Carboxylate

CAS: 1101854-58-3

4-Nitrophenyl4-(Bis(Benzo[D][1,3]Dioxol-5-Yl)(Hydroxy)Methyl)Piperidine-1-Carboxylate

Purity: 99%

Molecular weight: 520.5g/mol

Ref: 54-OR1025576

JZL 184

CAS: 1101854-58-3

JZL 184

Purity: ≥95%

Molecular weight: 520.49g/mol

Ref: 54-BUP10716

JZL 184

CAS: 1101854-58-3

Formula: C₂₇H₂₄N₂O₉

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 520.49

Ref: 3B-J0038

JZL 184

CAS: 1101854-58-3

JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.

Formula: C₂₇H₂₄N₂O₉

Purity: 97.56% - 99.31%

Color and Shape: Solid

Molecular weight: 520.49

Ref: TM-T6554

JZL 184

CAS: 1101854-58-3

JZL 184 is a drug that inhibits the enzyme monoacylglycerol lipase, which is involved in the production of endocannabinoids. This inhibition leads to decreased levels of 2-arachidonoylglycerol and monoacylglycerol. JZL 184 also inhibits the synthesis of proinflammatory cytokines and chemokines, leading to decreased inflammation. JZL 184 has been shown to have anti-cancer effects in mice by inhibiting tumor growth and metastasis through toll-like receptor 4 (TLR4) activation. It has also been shown to inhibit the production of inflammatory molecules and tumor necrosis factor alpha (TNFα) in cancer cells.

Formula: C₂₇H₂₄N₂O₉

Purity: Min. 95%

Molecular weight: 520.14818

Ref: 3D-BJ180308