CAS 110221-44-8

Temocapril hydrochloride

Description:

Temocapril hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. It is characterized by its ability to inhibit the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced blood pressure. The compound is typically presented as a white to off-white crystalline powder, which is soluble in water and exhibits a moderate stability profile. Its molecular structure includes a carboxyl group, which is essential for its pharmacological activity. Temocapril hydrochloride is often administered orally and is known for its relatively long half-life, allowing for once-daily dosing. Common side effects may include dizziness, cough, and elevated potassium levels, similar to other ACE inhibitors. As with any medication, it is important for patients to be monitored for potential adverse effects and interactions with other drugs. Overall, Temocapril hydrochloride represents a valuable option in the management of cardiovascular conditions.

Formula: C₂₃H₂₈N₂O₅S₂·HCl

InChI: InChI=1/C23H28N2O5S2/c1-2-30-23(29)17(11-10-16-7-4-3-5-8-16)24-18-15-32-20(19-9-6-12-31-19)13-25(22(18)28)14-21(26)27/h3-9,12,17-18,20,24H,2,10-11,13-15H2,1H3,(H,26,27)/t17-,18-,20-/m0/s1

InChI key: InChIKey=XDDQNOKKZKHBIX-ASBZXGSUSA-N

SMILES: C(C(O)=O)N1C[C@H](SC[C@H](N[C@@H](CCC2=CC=CC=C2)C(OCC)=O)C1=O)C3=CC=CS3.Cl

Synonyms:

• (2S,6R)-6-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid Hydrochloride
• 1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, hydrochloride (1:1), (2S,6R)-
• 1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, (2S,6R)-
• 1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, (2S,6R)- (9CI)
• 1,4-Thiazepine-4(5H)-acetic acid, 6-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, [2S-[2α,6β(R*)]]-
• Acecol
• Cs-622
• Temocapril Hcl
• TemocarpileHCL
• Temocarpilhydrochloride
• [(2S)-6-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl]acetic acid hydrochloride (1:1)
• [(2S,6R)-6-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl]acetic acid
• [(2S,6R)-6-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl]acetic acid hydrochloride (1:1)
• Temocapril hydrochloride
• 2-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)-2,5,6,7-tetrahydro-1,4-thiazepine-4(3H)-yl]acetic acid·hydrochloride

Temocapril hydrochloride

CAS: 110221-44-8

Formula: C₂₃H₂₉ClN₂O₅S₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 513.0698

Ref: IN-DA01CCL0

Temocapril HCl

CAS: 110221-44-8

Formula: C₂₃H₂₈N₂O₅S₂·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 476.62 36.46

Ref: 4Z-T-179001

Temocapril hydrochloride

CAS: 110221-44-8

Formula: C₂₃H₂₉ClN₂O₅S₂

Molecular weight: 513.07

Ref: 7W-GP8710

Temocapril hydrochloride

CAS: 110221-44-8

Temocapril hydrochloride

Purity: ≥98%

Molecular weight: 513.07g/mol

Ref: 54-BUP10652

Temocapril hydrochloride

CAS: 110221-44-8

Temocapril hydrochloride (CS-622 HCl), the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the therapy of hypertension.

Formula: C₂₃H₂₈N₂O₅S₂·HCl

Purity: 99.26% - 99.48%

Color and Shape: White Solid Powder

Molecular weight: 513.07

Ref: TM-T6698

Temocapril Hydrochloride

Controlled Product

CAS: 110221-44-8

Applications Angiotensin-converting enzyme (ACE) inhibitor. Hydrolyzed in vivo to the active diacid metabolite.
References Qizumi, K., et al.: Jpn. J. Pharmacol., 48, 349 (1988), Arita, M., et al.: Clin. Exp. Pharmacol. Physiol., 21, 195 (1994), Tokunaga, S., et al.: Drug Invest., 7, 161 (1994)

Formula: C₂₃H₂₈N₂O₅S₂·ClH

Color and Shape: Neat

Molecular weight: 513.07

Ref: TR-T017301

Temocapril hydrochloride

CAS: 110221-44-8

Angiotensin-converting enzyme inhibitor; anti-hypertensive

Formula: C₂₃H₂₉ClN₂O₅S₂

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 513.07 g/mol

Ref: 3D-FT28025