CAS 110221-53-9: Temocaprilat

Description: Temocaprilat is an angiotensin-converting enzyme (ACE) inhibitor, primarily used in the treatment of hypertension and heart failure. It is the active metabolite of temocapril, which is administered as a prodrug. Temocaprilat functions by inhibiting the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced blood pressure. The substance is characterized by its ability to improve cardiovascular outcomes by decreasing peripheral resistance and promoting renal blood flow. Chemically, it features a carboxylate group, which is crucial for its interaction with the ACE enzyme. Temocaprilat is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Its pharmacokinetics are influenced by factors such as renal function, as it is primarily excreted through the kidneys. Common side effects may include hypotension, dizziness, and renal impairment, necessitating monitoring during treatment. Overall, temocaprilat is an important therapeutic agent in managing conditions related to high blood pressure and heart function.

Formula: C₂₁H₂₄N₂O₅S₂

InChI: InChI=1S/C21H24N2O5S2/c24-19(25)12-23-11-18(17-7-4-10-29-17)30-13-16(20(23)26)22-15(21(27)28)9-8-14-5-2-1-3-6-14/h1-7,10,15-16,18,22H,8-9,11-13H2,(H,24,25)(H,27,28)/t15-,16-,18-/m0/s1

InChI key: InChIKey=KZVWEOXAPZXAFB-BQFCYCMXSA-N

SMILES: O=C(O)CN1C(=O)C(NC(C(=O)O)CCC=2C=CC=CC2)CSC(C=3SC=CC3)C1

Synonyms:

• (+)-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid
• (2S)-2-{[(2S)-4-(carboxymethyl)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-6-yl]amino}-4-phenylbutanoic acid
• (2S)-2-{[(2S,6R)-4-(carboxymethyl)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-6-yl]amino}-4-phenylbutanoic acid
• (2S,6R)-6-[[(1S)-1-Carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid
• 1,4-Thiazepine-4(5H)-acetic acid, 6-[(1-carboxy-3-phenylpropyl)amino]tetrahydro-5-oxo-2-(2-thienyl)-, [2S-[2α,6β(R*)]]-
• 1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, (2S,6R)-
• 2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-Phenyl-Propyl]Amino]-5-Oxo-2-Thiophen-2-Yl-1,4-Thiazepan-4-Yl]Acetic Acid
• Rs-5139
• Temocapril
• Temocapril Diacid
• Temocaprilat(Forr&Donly)
• Temocaprilate
• [(2S)-6-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl]acetic acid

Temocaprilat

CAS: 110221-53-9

• Formula: C₂₁H₂₄N₂O₅S₂
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 448.5557

Temocaprilat

CAS: 110221-53-9

• Formula: C₂₁H₂₄N₂O₅S₂
• Molecular weight: 448.56

Temocaprilat

CAS: 110221-53-9

Applications Antihypertensive. References Qizumi, K., et al.: Jpn. J. Pharmacol., 48, 349 (1988), Arita, M., …

• Formula: C₂₁H₂₄N₂O₅S₂
• Color and Shape: Neat
• Molecular weight: 448.56

Temocaprilat

CAS: 110221-53-9

Temocaprilat (RS5139) is an Angiotensin-converting Enzyme (ACE) inhibitor.

• Formula: C₂₁H₂₄N₂O₅S₂
• Purity: 96.88%
• Color and Shape: White To Off-White Solid
• Molecular weight: 448.56

Temocaprilat

CAS: 110221-53-9

Temocaprilat is a long-acting, orally active angiotensin-converting enzyme (ACE) inhibitor that is used for the …

• Formula: C₂₁H₂₄N₂O₅S₂
• Purity: Min. 95%
• Molecular weight: 448.56 g/mol