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CAS 11033-22-0

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Coformycin

Description:
Coformycin is a purine nucleoside analog that exhibits notable characteristics, primarily recognized for its role as an inhibitor of adenosine deaminase. This compound is derived from the fermentation of certain microorganisms, particularly Streptomyces species. Coformycin is structurally related to adenosine, featuring a ribose sugar moiety linked to a purine base, which allows it to interact with biological systems effectively. Its mechanism of action involves the inhibition of the enzyme adenosine deaminase, leading to increased levels of adenosine in tissues, which can have various pharmacological effects, including immunosuppressive properties. Coformycin has been studied for its potential therapeutic applications, particularly in the context of cancer and autoimmune diseases. Additionally, it is characterized by its solubility in water and organic solvents, which facilitates its use in biochemical assays and research. As with many bioactive compounds, the safety and efficacy of coformycin in clinical settings continue to be subjects of ongoing research.
Formula:C11H16N4O5
InChI:InChI=1S/C11H16N4O5/c16-2-6-8(18)9(19)11(20-6)15-4-14-7-5(17)1-12-3-13-10(7)15/h3-6,8-9,11,16-19H,1-2H2,(H,12,13)/t5-,6-,8-,9-,11-/m1/s1
InChI key:InChIKey=YOOVTUPUBVHMPG-LODYRLCVSA-N
SMILES:O[C@H]1[C@H](N2C3=C(N=C2)[C@H](O)CN=CN3)O[C@H](CO)[C@H]1O
Synonyms:
  • Imidazo[4,5-d][1,3]diazepin-8-ol, 3,4,7,8-tetrahydro-3-β-D-ribofuranosyl-, (8R)-
  • imidazo[4,5-d][1,3]diazepin-8-ol, 3,4,7,8-tetrahydro-3-beta-D-ribofuranosyl-, (8R)-
  • NSC 277817
  • Imidazo(4,5-d)(1,3)diazepin-8-ol, 3,4,7,8-tetrahydro-3-beta-D-ribofuranosyl-, (R)-
  • (8R)-3,4,7,8-Tetrahydro-3-β-D-ribofuranosylimidazo[4,5-d][1,3]diazepin-8-ol
  • Coformycin
  • Imidazo[4,5-d][1,3]diazepin-8-ol, 3,4,7,8-tetrahydro-3-β-D-ribofuranosyl-, (R)-
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  • Coformycin
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    Coformycin

    CAS:
    <p>Coformycin is a ribonucleoside antibiotic synergist and adenosine deaminase inhibitor.</p>
    Formula:C11H16N4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:284.27

    Ref: TM-T23905