CAS 1104-22-9

meclizine dihydrochloride

Description:

Meclizine dihydrochloride is an antihistamine primarily used to prevent and treat nausea, vomiting, and dizziness associated with motion sickness and vertigo. It is a white to off-white crystalline powder that is soluble in water and alcohol, making it suitable for various pharmaceutical formulations. The compound acts as a selective antagonist of the H1 histamine receptor, which helps to alleviate symptoms by blocking the effects of histamine in the body. Meclizine dihydrochloride has a relatively long duration of action, which contributes to its effectiveness in managing motion sickness. It is typically administered orally and may be available in tablet or chewable form. Common side effects can include drowsiness, dry mouth, and fatigue, which are typical of many antihistamines. Due to its sedative properties, caution is advised when operating machinery or driving after taking the medication. Overall, meclizine dihydrochloride is a valuable therapeutic agent in the management of vestibular disorders and motion-related symptoms.

Formula: C₂₅H₂₉Cl₃N₂

InChI: InChI=1/C25H27ClN2.ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;/h2-13,18,25H,14-17,19H2,1H3;1H

InChI key: InChIKey=VCTHNOIYJIXQLV-UHFFFAOYSA-N

SMILES: C(N1CCN(CC2=CC(C)=CC=C2)CC1)(C3=CC=C(Cl)C=C3)C4=CC=CC=C4.Cl

Synonyms:

• 1-(p-Chloro-α-phenylbenzyl)-4-(m-methylbenzyl)piperazine dihydrochloride
• 1-[(4-Chlorophenyl)(Phenyl)Methyl]-4-(3-Methylbenzyl)Piperazine
• 1-[(4-Chlorophenyl)(Phenyl)Methyl]-4-(3-Methylbenzyl)Piperazine Dihydrochloride
• 1-[(4-Chlorophenyl)(Phenyl)Methyl]-4-(3-Methylbenzyl)Piperazine Hydrochloride (1:1)
• 1-[(4-Chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine dihydrochloride
• Ancolan dihydrochloride
• Bonamine
• Diadril
• Meclizine hcl
• Meclizine hydrochloride
• Meclozine Dihydrochloride
• Meclozine hydrochloride
• NSC 28728
• Navidoxine
• Parachloramine dihydrochloride
• Piperazine, 1-(p-chloro-α-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride
• Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride
• Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, hydrochloride (1:2)
• Postafen
• Postafene dihydrochloride
• Zentrip
• Meclizine dihydrochloride
• Meclozine dihydrochloride monohydrate
• 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-piperazindihyd
• parachloraminedihydrochloride
• Meclizine diHCl
• ancolandihydrochloride
• meclozinedihydrochloride
• Piperazine, 1-(p-chloro-a-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride (6CI, 8CI)
• 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-piperazindihydrochlorid
• 1-p-chlorbenzhydryl-m-methylbenzylpiperazinedihydrochloride
• 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-piperazindih
• mecilizine hydrochloride
• 1-([4-CHLOROPHENYL]PHENYLMETHYL)-4-([3-METHYLPHENYL]-METHYL)PIPERAZINE DIHYDROCHLORIDE

Meclozine Dihydrochloride

CAS: 1104-22-9

Color and Shape: Neat

Ref: 61-FOR0586.00

MECLOZINE DIHYDROCHLORIDE CRS

CAS: 1104-22-9

MECLOZINE DIHYDROCHLORIDE CRS

Formula: C₂₅H₂₇ClN₂

Molecular weight: 390.9483

Ref: 41-M0220000

Meclozine hydrochloride

CAS: 1104-22-9

Meclozine hydrochloride

Color and Shape: Light Yellow Solid

Ref: 47-220

Meclizine dihydrochloride

CAS: 1104-22-9

Meclizine dihydrochloride (NSC28728) is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation

Formula: C₂₅H₂₇ClN₂·2HCl

Purity: 98.05% - 99.79%

Color and Shape: White Slightly Yellowish Crystalline Powder

Molecular weight: 463.87

Ref: TM-T1110

Meclizine DiHCl

CAS: 1104-22-9

Formula: C₂₅H₂₇ClN₂·2HCl

Color and Shape: White To Off-White Solid

Molecular weight: 390.96 2*36.46

Ref: 4Z-M-401

Meclizine Dihydrochloride

CAS: 1104-22-9

Meclizine Dihydrochloride

Purity: 98%

Molecular weight: 463.87g/mol

Ref: 54-OR1030341

Meclizine dihydrochloride

CAS: 1104-22-9

Meclizine dihydrochloride

Purity: ≥95%

Molecular weight: 463.87g/mol

Ref: 54-BUP17363

Meclizine dihydrochloride

CAS: 1104-22-9

Formula: C₂₅H₂₇ClN₂·2HCl

Purity: ≥ 97.0%

Color and Shape: White, off-white or beige powder

Molecular weight: 463.87

Ref: 7W-GP7447

Meclozine Dihydrochloride

CAS: 1104-22-9

Color and Shape: Neat

Ref: 86-MM0586.00

1-((4-Chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine dihydrochloride

CAS: 1104-22-9

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 463.8699951171875

Ref: 10-F079238

Meclizine Dihydrochloride

CAS: 1104-22-9

Applications Meclizine Dihydrochloride is a histamine H1 receptor antagonist with antiemetic properties. Meclizine Dihydrochloride is a research product for neuroscience. This compound may exhibit neuroprotective properties.
References Tran, V. T., et al.: Proc. Natl. Acad. Sci. USA 75, 6290 (1978).

Formula: C₂₅H₂₇ClN₂·2ClH

Color and Shape: Neat

Molecular weight: 463.87

Ref: TR-M202695

Meclizinedihydrochloride

CAS: 1104-22-9

Meclizine is a drug that is used to treat nausea and vomiting. It is also used as an anti-motion sickness medication, but it does not work well for people who have vertigo or balance disorders. Meclizine has been shown to be effective in the treatment of inflammatory bowel disease as well as spastic colon. It works by stabilizing the cell membrane, which inhibits the passage of substances across the membrane and thus reduces inflammation. Meclizine can also be used to prevent or treat cardiac arrhythmias, such as supraventricular tachycardia and atrial fibrillation. Meclizine helps to regulate metabolism by increasing levels of energy production in cells, which improves mental function when taken by geriatric patients with psychosis.

Formula: C₂₅H₂₉Cl₃N₂

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 463.87 g/mol

Ref: 3D-FM156453