CAS 110419-25-5

1-methyl-5-(2-deoxy-2-fluoroarabinofuranosyl)uracil

Description:

1-Methyl-5-(2-deoxy-2-fluoroarabinofuranosyl)uracil, identified by its CAS number 110419-25-5, is a nucleoside analog that exhibits structural modifications to the uracil base. This compound features a methyl group at the 1-position and a 2-deoxy-2-fluoroarabinofuranosyl moiety, which enhances its stability and bioavailability compared to natural nucleosides. The presence of the fluorine atom contributes to its unique properties, potentially affecting its interaction with nucleic acid synthesis and metabolism. This compound is of interest in medicinal chemistry, particularly in the development of antiviral and anticancer agents, as it may interfere with viral replication or tumor cell proliferation. Its solubility, stability under physiological conditions, and ability to mimic natural nucleosides make it a valuable candidate for further research. Additionally, the structural characteristics may influence its pharmacokinetics and pharmacodynamics, making it a subject of study in drug design and therapeutic applications.

Formula: C₁₀H₁₃FN₂O₅

InChI: InChI=1/C10H13FN2O5/c1-13-2-4(9(16)12-10(13)17)8-6(11)7(15)5(3-14)18-8/h2,5-8,14-15H,3H2,1H3,(H,12,16,17)/t5-,6+,7-,8?/m1/s1

Synonyms:

• 5-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-1-methyl-2,4(1H,3H)-pyrimidinedione
• 5-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-1-methyluracil
• 2,4(1H,3H)-Pyrimidinedione, 5-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-1-methyl-
• (1xi)-1,4-anhydro-2-deoxy-2-fluoro-1-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-arabinitol