CAS 11050-94-5: oligomycin B

Description: Oligomycin B is a macrolide antibiotic that is primarily known for its role as an inhibitor of ATP synthase, an essential enzyme in the process of oxidative phosphorylation in mitochondria. It is produced by the fermentation of certain Streptomyces species. Oligomycin B exhibits a complex structure characterized by a large lactone ring and multiple hydroxyl groups, contributing to its biological activity. This compound is particularly notable for its ability to inhibit proton translocation across the mitochondrial membrane, effectively blocking ATP production and leading to cellular energy depletion. In addition to its antibiotic properties, oligomycin B has been utilized in research to study mitochondrial function and energy metabolism. It is important to handle this compound with care, as it can have significant effects on cellular respiration and metabolism. Oligomycin B is typically used in laboratory settings, and its applications extend to pharmacological studies and investigations into mitochondrial diseases.

Formula: C₄₅H₇₂O₁₂

InChI: InChI=1/C45H72O12/c1-12-33-17-15-13-14-16-25(3)42(52)44(11,54)43(53)31(9)40(51)30(8)39(50)29(7)38(49)24(2)18-21-37(48)55-41-28(6)34(20-19-33)56-45(32(41)10)36(47)22-26(4)35(57-45)23-27(5)46/h13-15,17-18,21,24-35,38,40-42,46,49,51-52,54H,12,16,19-20,22-23H2,1-11H3/b14-13-,17-15+,21-18+/t24-,25+,26-,27+,28+,29-,30-,31-,32-,33-,34-,35-,38+,40+,41+,42-,44+,45+/m1/s1

InChI key: InChIKey=QPRQJOHKNJIMGN-WVUAJZTGSA-N

SMILES: O=C1OC2C(C)C(OC3(OC(CC(O)C)C(C)CC3=O)C2C)CCC(C=CC=CCC(C)C(O)C(O)(C(=O)C(C)C(O)C(C(=O)C(C)C(O)C(C=C1)C)C)C)CC

Synonyms:

• (1R,2′S,4E,5′S,6S,6′S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-22-Ethyl-5′,6′-dihydro-7,11,14,15-tetrahydroxy-6′-[(2R)-2-hydroxypropyl]-5′,6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2′-[2H]pyran]-3,3′,9,13(4′H)-tetrone
• (1S,5'R,6R,6'R,7S,8R,10S,11S,12R,14S,15R,16S,22S,25R,27R,28R,29S)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2S)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-5',6'-dihydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,3',9,13(4'H)-tetrone
• 22-ethyl-7,11,14,15-tetrahydroxy-6'-(2-hydroxypropyl)-5',6,8,10,12,14,16,28,29-nonamethyl-5',6'-dihydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,3',9,13(4'H)-tetrone
• Brn 5705502
• Oligomycin A, 28-oxo-
• Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2′-[2H]pyran]-3,3′,9,13(4′H)-tetrone, 22-ethyl-5′,6′-dihydro-7,11,14,15-tetrahydroxy-6′-(2-hydroxypropyl)-5′,6,8,10,12,14,16,28,29-nonamethyl-, [1R-[1R*,4E,5′S*,6S*,6′S*(R*),7R*,8S*,10R*,11R*,12S*,14R*,15S*,16R*,18E,20E,22R*,25S*,27S*,28S*,29R*]]-
• Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2′-[2H]pyran]-3,3′,9,13(4′H)-tetrone, 22-ethyl-5′,6′-dihydro-7,11,14,15-tetrahydroxy-6′-[(2R)-2-hydroxypropyl]-5′,6,8,10,12,14,16,28,29-nonamethyl-, (1R,2′S,4E,5′S,6S,6′S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-
• Oligomycin B

Oligomycin B

CAS: 11050-94-5

• Formula: C₄₅H₇₂O₁₂
• Purity: 78.65%
• Color and Shape: White. Solid
• Molecular weight: 805.0

Oligomycin B from Streptomyces diastatochromogenes

CAS: 11050-94-5

• Formula: C₄₅H₇₂O₁₂
• Purity: By hplc: 99.62% (Typical Value in Batch COA)
• Color and Shape: white powder
• Molecular weight: 805.05g/mol

Oligomycin B

CAS: 11050-94-5

• Formula: C₄₅H₇₂O₁₂
• Molecular weight: 805.1

Oligomycin B

CAS: 11050-94-5

Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, …

• Formula: C₄₅H₇₂O₁₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 805.05

Oligomycin B

CAS: 11050-94-5

Please enquire for more information about Oligomycin B including the price, delivery time and more …

• Formula: C₄₅H₇₂O₁₂
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 805.05 g/mol