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CAS 110503-61-2

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N-desmethyltoremifene

Description:
N-desmethyltoremifene is a chemical compound that serves as a metabolite of toremifene, a selective estrogen receptor modulator (SERM) primarily used in the treatment of breast cancer. This compound is characterized by its structural modifications, which include the removal of a methyl group from the toremifene molecule. N-desmethyltoremifene exhibits estrogenic and anti-estrogenic properties, influencing estrogen receptor activity in various tissues. It is typically studied for its pharmacological effects and potential therapeutic applications, particularly in oncology. The compound is soluble in organic solvents and has a relatively low solubility in water, which can affect its bioavailability and pharmacokinetics. Its chemical behavior is influenced by the presence of functional groups that can participate in various chemical reactions. As with many SERMs, understanding the pharmacodynamics and pharmacokinetics of N-desmethyltoremifene is crucial for evaluating its efficacy and safety in clinical settings.
Formula:C25H26ClNO
InChI:InChI=1/C25H26ClNO/c1-27-18-19-28-23-14-12-22(13-15-23)25(21-10-6-3-7-11-21)24(16-17-26)20-8-4-2-5-9-20/h2-15,27H,16-19H2,1H3/b25-24-
SMILES:CNCCOc1ccc(cc1)/C(=C(/CCCl)\c1ccccc1)/c1ccccc1
Synonyms:
  • 2-(4-((1Z)-4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)-N-methylethanamine
  • N-Demethyltoremifene
  • Ethanamine, 2-(4-(4-chloro-1,2-diphenyl-1-butenyl)phenoxy)-N-methyl-, (Z)-
  • 2-{4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}-N-methylethanamine
  • N-Desmethyltoremifene
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Found 2 products.
  • N-Desmethyl Toremifene-d4
    TLC
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    N-Desmethyl Toremifene-d4

    CAS:
    Formula:C25H22ClNOD4
    Molecular weight:395.95

    Ref: 4Z-T-414

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  • N-Desmethyltoremifene
    Biosynth
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    N-Desmethyltoremifene

    CAS:
    <p>N-Desmethyltoremifene is an anti-estrogen that has been shown to have genotoxic effects. It inhibits DNA synthesis and protein synthesis in human breast cancer cells. N-Desmethyltoremifene is a potent inducer of CYP3A4, which metabolizes many drugs. This drug also binds to α1-acid glycoprotein, which can lead to reduced plasma concentrations and pharmacokinetics. N-Desmethyltoremifene has been shown to inhibit the growth of renal cell carcinoma in animals, but not normal tissue, at high doses.</p>
    Formula:C25H26ClNO
    Purity:Min. 95%
    Molecular weight:391.93 g/mol

    Ref: 3D-ID158043

    ne
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