CAS 11052-72-5

oligomycin C

Description:

Oligomycin C is a macrolide antibiotic that is primarily known for its role as an inhibitor of ATP synthase, an essential enzyme in the process of oxidative phosphorylation in mitochondria. It is derived from the bacterium Streptomyces diastaticus and is characterized by its complex structure, which includes a large lactone ring and multiple hydroxyl groups. Oligomycin C exhibits potent antifungal and antibacterial properties, making it valuable in research and potential therapeutic applications. Its mechanism of action involves binding to the F0 subunit of ATP synthase, effectively blocking proton translocation and thereby inhibiting ATP production. This action can lead to cellular energy depletion, which is particularly detrimental to rapidly dividing cells. Oligomycin C is often used in biochemical studies to investigate mitochondrial function and energy metabolism. However, due to its specificity and potency, it is important to handle this compound with care in laboratory settings. Its CAS number, 11052-72-5, is used for identification in chemical databases and regulatory frameworks.

Formula: C₄₅H₇₄O₁₀

InChI: InChI=1/C45H74O10/c1-12-35-17-15-13-14-16-26(3)39(48)30(7)41(50)32(9)43(52)33(10)42(51)31(8)40(49)27(4)18-21-38(47)53-44-29(6)36(20-19-35)54-45(34(44)11)23-22-25(2)37(55-45)24-28(5)46/h13-15,17-18,21,25-37,39-40,43-44,46,48-49,52H,12,16,19-20,22-24H2,1-11H3

InChI key: InChIKey=CMMLZMMKTYEOKV-RDKHTNMBSA-N

SMILES: CCC1C=CC=CCC(C)C(C(C)C(=O)C(C)C(C(C)C(=O)C(C)C(C(C)C=CC(=O)OC2C(C)C(CC1)OC1(CCC(C)C(CC(C)O)O1)C2C)O)O)O

Synonyms:

• (1R,2′R,4E,5′S,6S,6′S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-22-Ethyl-3′,4′,5′,6′-tetrahydro-7,11,15-trihydroxy-6′-[(2R)-2-hydroxypropyl]-5′,6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2′-[2H]pyran]-3,9,13-trione
• 22-ethyl-7,11,15-trihydroxy-6'-(2-hydroxypropyl)-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione
• Oligomycin A, 12-deoxy-
• Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2′-[2H]pyran]-3,9,13-trione, 22-ethyl-3′,4′,5′,6′-tetrahydro-7,11,15-trihydroxy-6′-[(2R)-2-hydroxypropyl]-5′,6,8,10,12,14,16,28,29-nonamethyl-, (1R,2′R,4E,5′S,6S,6′S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-
• Spiro[2,26-dioxabicyclo[23.3.1]nonacosane-27,2′-[2H]pyran], oligomycin A deriv.
• Oligomycin C
• Oligmycin C
• 12-Deoxyoligomycin A
• Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-
• OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES

Oligomycin C

CAS: 11052-72-5

Oligomycin C is an antifungal agent isolated from Streptomyces strain.

Formula: C₄₅H₇₄O₁₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 775.06

Ref: TM-T12299

Oligomycin C

CAS: 11052-72-5

Oligomycin C

Formula: C₄₅H₇₄O₁₀

Purity: By hplc: 100% (Typical Value in Batch COA)

Color and Shape: white powder

Molecular weight: 775.06g/mol

Ref: 54-BIO1007

Oligomycin C

CAS: 11052-72-5

Molecular weight: 775.06

Ref: 7W-GA9905

Oligomycin C 97%

CAS: 11052-72-5

Oligomycin C 97% is a macrolide antibiotic with action on mitochondrial ATP synthase inhibition and is used for research on oxidative phosphorylation and cellular metabolism.

Formula: C₄₅H₇₂O₁₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 805.05 g/mol

Ref: 3D-AO65696