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CAS 110543-74-3

:

5'-O-(4,4'-DIMETHOXYTRITYL)-N6-PHENOXYACETYL-2'-DEOXYADENOSINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE

Description:
5'-O-(4,4'-Dimethoxytrityl)-N6-Phenoxyacetyl-2'-deoxyadenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is a complex chemical compound primarily used in the field of nucleic acid synthesis, particularly for the solid-phase synthesis of oligonucleotides. This compound features a deoxyadenosine nucleoside, which is modified at the 5' position with a dimethoxytrityl (DMT) protecting group, enhancing its stability and solubility during synthesis. The N6-phenoxyacetyl modification provides additional protection to the amine group, while the 3' phosphoramidite functionality allows for the coupling reaction necessary for oligonucleotide assembly. The presence of the cyanoethyl group contributes to the stability of the phosphoramidite bond, facilitating the formation of phosphodiester linkages. This compound is characterized by its high reactivity, specificity in coupling reactions, and ability to form stable oligonucleotide chains, making it a valuable reagent in molecular biology and genetic research. Proper handling and storage conditions are essential to maintain its integrity and reactivity.
Formula:C48H54N7O8P
Synonyms:
  • DMT-dA(tac) amidite
  • DMT-dA(PAc) Phosphoramidite
  • 5''-O-(4,4''-Dimethoxytrityl)-N6-Phenoxyacetyl-2''-deoxyadenosine-3''-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(phenoxyacetyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
  • 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine 3'-CE phosphoramidite
  • 5'-O-(4,4'-DIMETHOXYTRITYL)-N6-PHENOXYACETYL-2'-DEOXYADENOSINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE
  • 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(phenoxyacetyl)-adenosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
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