CymitQuimica logo

CAS 11056-06-7

:

Bleomycin

Description:
Bleomycin is a glycopeptide antibiotic that is primarily used in cancer chemotherapy. It is derived from the bacterium Streptomyces verticillus and is known for its ability to induce DNA strand breaks, which leads to the inhibition of cancer cell growth. The compound exhibits a unique mechanism of action by binding to DNA and generating free radicals in the presence of oxygen, resulting in oxidative damage. Bleomycin is particularly effective against certain types of tumors, including testicular cancer and Hodgkin's lymphoma. It is administered via injection and can cause side effects such as pulmonary toxicity, skin reactions, and fever. The substance is characterized by its relatively low molecular weight and a complex structure that includes a metal-binding site, which is crucial for its activity. Due to its specific action on rapidly dividing cells, Bleomycin is often used in combination with other chemotherapeutic agents to enhance treatment efficacy while minimizing resistance. Its use requires careful monitoring due to potential adverse effects, particularly on lung function.
Formula:Unspecified
InChI:InChI=1/C55H83N17O21S3/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88)/p+1/t21-,22+,23+,24-,25-,29?,30?,34-,35-,36-,37?,38?,39?,40?,41-,42?,43?,53?,54?/m0/s1
Synonyms:
  • Blenamax
  • Bleo
  • Bleo-Kyowa
  • Bleocin
  • Bleomycins
  • Nsc 125066
  • [2-[2-[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxo-propyl)amino]-3-oxo-propyl]-5-methyl-pyrimidine-4-carbonyl]amino]-3-[[4-[[1-[2-[4-[4-(4-guanidinobutylcarbamoyl)thiazol-2-yl]thiazol-2-yl]ethylcarbamoyl]-2-hydroxy-propyl]amino]-2-hydroxy-1,3-dimethyl-4-oxo-butyl]amino]-1-(3H-imidazol-4-yl)-3-oxo-propoxy]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl] carbamate
  • (3-{[(2'-{(5S,8S,9S,10R,13S)-15-{6-amino-2-[(1S)-3-amino-1-{[(2S)-2,3-diamino-3-oxopropyl]amino}-3-oxopropyl]-5-methylpyrimidin-4-yl}-13-[(R)-{[3-{[4-(carbamoyloxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}(1H-imidazol-5-yl)methyl]-9-hydroxy-5-[(1R)-1-hydroxyethyl]-8,10-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazapentadec-1-yl}-2,4'-bi-1,3-thiazol-4-yl)carbonyl]amino}propyl)(dimethyl)sulfonium (non-preferred name)
  • N1-(3-(dimethylsulfonio)propyl)bleomycinamide) (Bleomycin A2)
  • BLM
  • See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 3 products.
  • Bleomycin Sulfate (mixture)
    TCI
    + Info

    Bleomycin Sulfate (mixture)

    CAS:
    Purity:>85.0%(HPLC)
    Color and Shape:White to Light yellow powder to crystal

    Ref: 3B-B3972

    10mg
    162.00€
    50mg
    608.00€
  • Bleomycin
    Biosynth
    + Info

    Bleomycin

    CAS:
    <p>Bleomycin is an antineoplastic antibiotic, which is derived from the bacterium *Streptomyces verticillus*. Its mode of action involves binding to DNA and inducing strand breaks through the generation of free radicals, particularly in regions rich in guanine and cytosine. This leads to inhibition of DNA synthesis and, consequently, cellular replication, making it effective in targeting rapidly dividing cancer cells.</p>
    Formula:C55H84N17O21S3
    Purity:Min. 95%
    Molecular weight:1,415.56 g/mol

    Ref: 3D-AB30158

    ne
    To inquire
  • CymitQuimica logo
    Targetmol
    + Info

    Bleomycin Free Base

    CAS:
    <p>Bleomycin Free Base, a glycopeptide antibiotic, halts DNA function and treats solid tumors.</p>
    Formula:C55H84N17O21S3
    Color and Shape:Solid
    Molecular weight:1415.55

    Ref: TM-T71445