CAS 110588-56-2: Noberastine

Description: Noberastine is a chemical compound classified as an antihistamine, primarily used for its potential therapeutic effects in treating allergic conditions. It functions by selectively antagonizing histamine H1 receptors, thereby alleviating symptoms associated with allergies, such as itching, sneezing, and runny nose. The compound is characterized by its ability to cross the blood-brain barrier, which may lead to central nervous system effects, although it is generally considered to have a lower sedative profile compared to first-generation antihistamines. Noberastine exhibits a favorable pharmacokinetic profile, including good oral bioavailability and a moderate half-life, allowing for effective dosing regimens. Its chemical structure includes specific functional groups that contribute to its biological activity and receptor selectivity. As with many antihistamines, potential side effects may include drowsiness, dry mouth, and dizziness, although these are typically less pronounced than those associated with older antihistamines. Overall, Noberastine represents a modern approach to allergy management, with ongoing research into its efficacy and safety profile.

Formula: C₁₇H₂₁N₅O

InChI: InChI=1/C17H21N5O/c1-12-4-5-14(23-12)11-22-16-15(3-2-8-19-16)21-17(22)20-13-6-9-18-10-7-13/h2-5,8,13,18H,6-7,9-11H2,1H3,(H,20,21)

Synonyms:

• Noberastine [USAN:INN:BAN]
• Noberastinum
• Noberastinum [INN-Latin]
• Noberastina
• R 64947
• 3-[(5-methylfuran-2-yl)methyl]-N-(piperidin-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine
• UNII-9HPD98OUWN
• Noberastina [INN-Spanish]
• 3H-Imidazo(4,5-b)pyridin-2-amine, 3-((5-methyl-2-furanyl)methyl)-N-4-piperidinyl-
• 3-(5-Methylfurfuryl)-2-(4-piperidylamino)-3H-imidazo(4,5-b)pyridine

Noberastine

CAS: 110588-56-2

Noberastine (R 64947) is a novel histamine H1 antagonist with potent and specific peripheral antihistamine …

• Formula: C₁₇H₂₁N₅O
• Purity: 100% - 99.67%
• Color and Shape: Solid
• Molecular weight: 311.38