CAS 11061-68-0
:insulin human
Description:
Insulin human, with the CAS number 11061-68-0, is a peptide hormone produced by the pancreas that plays a crucial role in glucose metabolism. It is composed of 51 amino acids and has a molecular weight of approximately 5,800 daltons. Insulin functions primarily to lower blood glucose levels by facilitating the uptake of glucose into cells, particularly in muscle and adipose tissue, and by inhibiting hepatic glucose production. The structure of insulin consists of two chains, A and B, linked by disulfide bonds, which are essential for its biological activity. Insulin is typically administered via injection due to its protein nature, as it is not effective when taken orally due to degradation in the gastrointestinal tract. It is used therapeutically in the management of diabetes mellitus, helping to control blood sugar levels in individuals with insulin deficiency or resistance. Insulin human is produced through recombinant DNA technology, ensuring a consistent and safe supply for medical use.
Formula:C257H383N65O77S6
InChI:InChI=1/C257H383N65O77S6/c1-29-131(23)205(313-193(339)104-259)252(393)317-204(130(21)22)248(389)288-159(75-82-200(349)350)217(358)282-156(71-78-189(263)335)221(362)308-183-116-403-404-117-184-243(384)305-178(111-324)240(381)294-162(88-123(7)8)225(366)295-168(95-140-53-61-146(329)62-54-140)228(369)283-154(69-76-187(261)333)218(359)290-161(87-122(5)6)223(364)285-158(74-81-199(347)348)220(361)302-174(101-190(264)336)235(376)298-170(97-142-57-65-148(331)66-58-142)231(372)309-182(242(383)304-176(255(396)397)103-192(266)338)115-402-401-114-181(214(355)273-107-194(340)278-153(72-79-197(343)344)216(357)281-151(51-42-84-271-257(267)268)212(353)272-108-195(341)279-166(93-138-46-36-32-37-47-138)227(368)297-167(94-139-48-38-33-39-49-139)230(371)299-171(98-143-59-67-149(332)68-60-143)238(379)320-208(135(27)327)254(395)322-85-43-52-186(322)246(387)286-152(50-40-41-83-258)222(363)321-209(136(28)328)256(398)399)311-250(391)203(129(19)20)316-236(377)164(90-125(11)12)292-229(370)169(96-141-55-63-147(330)64-56-141)296-224(365)160(86-121(3)4)289-210(351)133(25)277-215(356)157(73-80-198(345)346)287-247(388)202(128(17)18)315-237(378)165(91-126(13)14)293-233(374)173(100-145-106-270-120-276-145)301-239(380)177(110-323)280-196(342)109-274-213(354)180(113-400-405-118-185(310-244(183)385)245(386)319-207(134(26)326)253(394)306-179(112-325)241(382)318-206(132(24)30-2)251(392)312-184)307-226(367)163(89-124(9)10)291-232(373)172(99-144-105-269-119-275-144)300-219(360)155(70-77-188(262)334)284-234(375)175(102-191(265)337)303-249(390)201(127(15)16)314-211(352)150(260)92-137-44-34-31-35-45-137/h31-39,44-49,53-68,105-106,119-136,150-186,201-209,323-332H,29-30,40-43,50-52,69-104,107-118,258-260H2,1-28H3,(H2,261,333)(H2,262,334)(H2,263,335)(H2,264,336)(H2,265,337)(H2,266,338)(H,269,275)(H,270,276)(H,272,353)(H,273,355)(H,274,354)(H,277,356)(H,278,340)(H,279,341)(H,280,342)(H,281,357)(H,282,358)(H,283,369)(H,284,375)(H,285,364)(H,286,387)(H,287,388)(H,288,389)(H,289,351)(H,290,359)(H,291,373)(H,292,370)(H,293,374)(H,294,381)(H,295,366)(H,296,365)(H,297,368)(H,298,376)(H,299,371)(H,300,360)(H,301,380)(H,302,361)(H,303,390)(H,304,383)(H,305,384)(H,306,394)(H,307,367)(H,308,362)(H,309,372)(H,310,385)(H,311,391)(H,312,392)(H,313,339)(H,314,352)(H,315,378)(H,316,377)(H,317,393)(H,318,382)(H,319,386)(H,320,379)(H,321,363)(H,343,344)(H,345,346)(H,347,348)(H,349,350)(H,396,397)(H,398,399)(H4,267,268,271)/t131-,132-,133-,134?,135?,136?,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,201-,202-,203-,204-,205-,206-,207-,208-,209-/m0/s1
Synonyms:- Insulin, Zinc, Human, Recomb.
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Found 14 products.
Insulin solution (4mg/mL) [Optimized for Cell Culture]
CAS:Color and Shape:Colorless to Almost colorlessclear liquidInsulin Human
CAS:Insulin and its saltsFormula:C257H383N65O77S6Color and Shape:White Lyophilized CakeMolecular weight:5803.63765High Molecular Weight Insulin Human
CAS:Insulin and its saltsFormula:C257H383N65O77S6(monomer)Color and Shape:White Off-White PowderMolecular weight:5803.63765Insulin Human, recombinant
CAS:Formula:C257H383N65O77S6Purity:95.0 - 105.0 % (dried basis)Color and Shape:White to off-white powderMolecular weight:5807.57Insulin (human)
CAS:<p>Insulin (human) is a peptide hormone that promotes glycogen synthesis and regulates glucose levels in the blood.</p>Formula:C257H383N65O77S6Purity:97.32% - 99.99%Color and Shape:SolidMolecular weight:5807.57Insulin (Human)
CAS:<p>Applications Insulin (Human) is a peptide hormone regulating the metabolism of carbohydrates and fats. It is used in the treatment of those suffering from the diabetes type I and II metabolic disorders. Regulates the absorption of glucose from the blood to skeletal muscles and fat storage.<br>References Lai, Y. et al.: Biochem. J., 460, 363 (2014); Hedman, C. et al.: Clin. Endocrinol., 81, 58 (2014);<br></p>Formula:C257H383N65O77S6Color and Shape:NeatMolecular weight:5807.57Insulin (Human)
CAS:<p>Insulin is a peptide hormone that regulates the uptake and storage of glucose by muscle and fat cells. Insulin is produced by beta cells in the pancreas, which release it into the bloodstream when blood sugar levels rise. Insulin lowers glucose levels by increasing the amount of glucose taken up from the blood into muscle and fat cells, suppressing hepatic gluconeogenesis, and promoting glycolysis. It also increases protein synthesis, decreases proteolysis, and stimulates growth. With a molecular weight of 5808 Da, insulin is composed of two polypeptide chains with an approximate molecular weight of 3120 Da each linked by disulfide bonds. Insulin has no lipid moiety or carbohydrate moiety.<br>Insulin binds to its receptor on the surface of a cell to trigger one or more signaling cascades leading to changes in metabolism. Binding to the receptor triggers a conformational change in the receptor that causes insulin to be released from its binding site on the receptor.</p>Formula:C257H383N65O77S6Purity:Min. 95%Molecular weight:5,807.6 g/molInsulin
CAS:<p>Insulin is a hormone that is produced by beta cells in the pancreas and regulates blood sugar levels. It is used for the treatment of diabetes mellitus, a disease in which the body does not produce enough insulin or cannot use insulin properly. Insulin works by lowering the level of glucose (sugar) in the blood, thereby regulating its supply to various parts of the body. Insulin has been shown to be effective at reducing postprandial blood glucose concentrations. This drug also lowers blood glucose concentrations by stimulating glucose uptake into muscle and adipose tissue. Insulin is also used to treat type 1 diabetes, gestational diabetes, and other conditions where low insulin production results in high blood sugar levels.</p>Formula:C257H383N65O77S6Purity:Reported (%)Color and Shape:PowderMolecular weight:5,807.57 g/molInsulin (Human)
CAS:<p>Human insulin is a peptide hormone produced by beta cells in the pancreas. The insulin receptor is found on the surface of liver, fat, and muscle cells. When binding to its receptor, insulin opens ion channels allowing potassium ions to flow into the cell and sodium ions to flow out of the cell. This change in ion concentration causes an electrical potential across the membrane that triggers an influx of calcium ions from outside the cell. These changes result in an increase in glucose uptake by tissues and inhibition of glucose production by the liver. Insulin also binds to a secondary receptor called IGF-1R (insulin-like growth factor) which activates intracellular signaling pathways involving PI3K and Akt kinase. Insulin can be used as a research tool for studying protein-protein interactions or as a pharmacological agent for diabetes treatment. <br>This product is enzymatically derived from Porcine Insulin A-chain, available as a 0.5mg vial and contains disulfide bonds between CysA6-CysA11,CysA7-CysB7, and CysA20-CysB19.</p>Formula:C257H383N65O77S6Purity:Min. 95%Molecular weight:5,807.6 g/molr-Insulin ex. Human for cell culture, 25 USP U/mg, Endotoxin (BET) 1.0EU/mg
CAS:Formula:C257H383N65O77S6Color and Shape:White, PowderMolecular weight:~ 5808Insulin Human (COLD SHIPMENT REQUIRED) (DISCONTINUED)
CAS:Insulin and its saltsFormula:C257H383N65O77S6Color and Shape:White CrystalsMolecular weight:5803.63765Ref: IN-DA008RHX
Discontinued product
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