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CAS 110652-73-8

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porothramycin A

Description:
Porothramycin A is a natural product classified as a macrolide antibiotic, originally isolated from the fermentation broth of certain Streptomyces species. It exhibits a complex structure characterized by a large lactone ring, which is typical of macrolides, and contains multiple functional groups that contribute to its biological activity. Porothramycin A has demonstrated significant antibacterial properties, particularly against Gram-positive bacteria, making it of interest in the field of medicinal chemistry and antibiotic development. Its mechanism of action is believed to involve inhibition of protein synthesis, similar to other macrolide antibiotics. Additionally, research has indicated potential antitumor activity, suggesting a broader pharmacological profile. The compound's stability, solubility, and bioavailability are important factors that influence its therapeutic potential. As with many natural products, the synthesis and modification of porothramycin A could lead to derivatives with enhanced efficacy or reduced side effects, making it a subject of ongoing research in drug discovery and development.
Formula:C18H21N3O4
InChI:InChI=1/C18H21N3O4/c1-20(2)15(22)8-7-11-9-13-17(23)19-16-12(18(24)21(13)10-11)5-4-6-14(16)25-3/h4-8,10,13,17,19,23H,9H2,1-3H3/b8-7+/t13?,17-/m1/s1
Synonyms:
  • Porothramycin
  • (2E)-N,N-Dimethyl-3-[[(11R,11aS)-5,10,11,11a-tetrahydro-11α-hydroxy-9-methoxy-5-oxo-1H-pyrrolo[2,1-c][1,4]benzodiazepin]-2-yl]propenamide
  • 2-Propenamide, N,N-dimethyl-3-[(11R,11aS)-5,10,11,11a-tetrahydro-11-hydroxy-9-methoxy-5-oxo-1H-pyrrolo[2,1-c][1,4]benzodiazepin-2-yl]-, (2E)-
  • BMY-28121A
  • (2E)-3-[(11R)-11-hydroxy-9-methoxy-5-oxo-5,10,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-2-yl]-N,N-dimethylprop-2-enamide
  • Antibiotic BMY-28121A
  • Porothramycin A
  • 2-Propenamide, N,N-dimethyl-3-(5,10,11,11a-tetrahydro-11-hydroxy-9-methoxy-5-oxo-1H-pyrrolo(2,1-c)(1,4)benzodiazepin-2-yl)-, (11R-(2(E),11-alpha,11a-beta))-
  • porothramycin A
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