CAS 110703-94-1

Zopolrestat

Description:

Zopolrestat is a chemical compound primarily recognized for its role as an aldose reductase inhibitor, which is significant in the management of diabetic complications. It is characterized by its ability to inhibit the enzyme aldose reductase, thereby reducing the conversion of glucose to sorbitol, a process implicated in diabetic neuropathy and other complications. The molecular structure of Zopolrestat includes specific functional groups that contribute to its inhibitory activity, making it a subject of interest in pharmacological research. Its efficacy and safety profile have been evaluated in various studies, highlighting its potential therapeutic applications. Additionally, Zopolrestat's solubility, stability, and interaction with biological systems are critical factors that influence its pharmacokinetics and pharmacodynamics. As with many pharmaceutical compounds, understanding its characteristics is essential for optimizing its use in clinical settings and for further development in treating diabetes-related conditions.

Formula: C₁₉H₁₂F₃N₃O₃S

InChI: InChI=1/C19H12F3N3O3S/c20-19(21,22)10-5-6-15-14(7-10)23-16(29-15)9-25-18(28)12-4-2-1-3-11(12)13(24-25)8-17(26)27/h1-7H,8-9H2,(H,26,27)

SMILES: c1ccc2c(c1)c(CC(=O)O)nn(Cc1nc3cc(ccc3s1)C(F)(F)F)c2=O

Synonyms:

• Zopolrestat [USAN:INN:BAN]
• 1-Phthalazineacetic acid, 3,4-dihydro-4-oxo-3-((5-(trifluoromethyl)-2-benzothiazolyl)methyl)-
• 3,4-Dihydro-4-oxo-3-((5-(trifluoromethyl)-2-benzothiazolyl)methyl)-1-phthalazineacetic acid
• Cp 73850
• Unii-1Pv3S9Wp3D
• Zopolrestatum
• Zopolrestatum [INN-Latin]
• (4-Oxo-3-{[5-(Trifluoromethyl)-1,3-Benzothiazol-2-Yl]Methyl}-3,4-Dihydrophthalazin-1-Yl)Acetic Acid

Zopolrestat

CAS: 110703-94-1

Zopolrestat

Purity: ≥98%

Molecular weight: 419.38g/mol

Ref: 54-BUP01891

2-(4-Oxo-3-((5-(Trifluoromethyl)Benzo[D]Thiazol-2-Yl)Methyl)-3,4-Dihydrophthalazin-1-Yl)Acetic Acid

CAS: 110703-94-1

2-(4-Oxo-3-((5-(Trifluoromethyl)Benzo[D]Thiazol-2-Yl)Methyl)-3,4-Dihydrophthalazin-1-Yl)Acetic Acid

Purity: 98%

Molecular weight: 419.38g/mol

Ref: 54-PC108525

Zopolrestat

CAS: 110703-94-1

Formula: C₁₉H₁₂F₃N₃O₃S

Molecular weight: 419.38

Ref: 7W-GK9413

Zopolrestat

CAS: 110703-94-1

Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).

Formula: C₁₉H₁₂F₃N₃O₃S

Purity: 99.74%

Color and Shape: Solid

Molecular weight: 419.38

Ref: TM-T35317