CAS 110764-79-9: Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

Description: Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a complex nucleoside derivative characterized by its unique structural features that enhance its stability and reactivity. This compound contains a uridine base, which is a nucleoside composed of a ribose sugar and a uracil base, modified at the 5' and 3' positions. The presence of the bis(4-methoxyphenyl)phenylmethyl group at the 5' position contributes to its lipophilicity and potential for improved cellular uptake. The 2'-O-methyl modification enhances resistance to enzymatic degradation, making it suitable for therapeutic applications. The 3' position features a cyanoethyl phosphoramidite moiety, which is commonly used in oligonucleotide synthesis, allowing for the incorporation of this modified nucleoside into RNA or DNA strands. Overall, this compound exhibits properties that make it valuable in biochemical research and potential therapeutic applications, particularly in the field of nucleic acid chemistry.

Formula: C₄₀H₄₉N₄O₉P

InChI: InChI=1S/C40H49N4O9P/c1-27(2)44(28(3)4)54(51-25-11-23-41)53-36-34(52-38(37(36)49-7)43-24-22-35(45)42-39(43)46)26-50-40(29-12-9-8-10-13-29,30-14-18-32(47-5)19-15-30)31-16-20-33(48-6)21-17-31/h8-10,12-22,24,27-28,34,36-38H,11,25-26H2,1-7H3,(H,42,45,46)/t34-,36-,37-,38-,54?/m1/s1

InChI key: InChIKey=UVUOJOLPNDCIHL-XKZJCBTISA-N

SMILES: N#CCCOP(OC1C(OC(N2C=CC(=O)NC2=O)C1OC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

Synonyms:

• 2'-O-Methyl-5'-O-DMT-Uridine-3'-CE-Phosphoramidite
• 5'-O-(4,4-Dimethoxytrityl)-2'-O-Methyluridine-3'-(2-Cyanoethyl-N,N-Diisopropyl)Phosphoramidite
• Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
• Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• DMT-2-O-ME-U-CE Phosphoramidite

DMT-2'-O-methyl-rU Phosphoramidite

CAS: 110764-79-9

• Formula: C₄₀H₄₉N₄O₉P
• Purity: >98.0%(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 760.82

5'-O-(4,4-Dimethoxytrityl)-2'-O-methyluridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

CAS: 110764-79-9

• Formula: C₄₀H₄₉N₄O₉P
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 760.8122

5''-O-DMT-2''-O-methyluridine 3''-CE phosphoramidite

CAS: 110764-79-9

5’-O-(4,4’-Dimethoxytrityl)-2’-O-Methyluridine-3’-(2-Cyanoethyl-N,N-Diisopropyl)Phosphoramidite

CAS: 110764-79-9

• Purity: 0.98
• Molecular weight: 760.81g/mol

DMT-2'O-Methyl-rU Phosphoramidite

CAS: 110764-79-9

• Molecular weight: 760.825

5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite

CAS: 110764-79-9

5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite is a modified, phosphoramidite nucleoside. It is used in the synthesis of …

• Formula: C₄₀H₄₉N₄O₉P
• Purity: Min. 98 Area-%
• Color and Shape: White Powder
• Molecular weight: 760.83 g/mol