![Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-, 3′-[2-cyanoethyl N,N-bis(1-methylet…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fcas-image%2Fthumb-webp%2F254759-uridine-5-o-bis-4-methoxyphenyl-phenylmethyl-2-o-methyl-3-2-cyanoethyl-n-n-bis-1-methylethyl-phosphoramidite.webp&w=3840&q=75)
CAS 110764-79-9
:Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
Description:
Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a complex nucleoside derivative characterized by its unique structural features that enhance its stability and reactivity. This compound contains a uridine base, which is a nucleoside composed of a ribose sugar and a uracil base, modified at the 5' and 3' positions. The presence of the bis(4-methoxyphenyl)phenylmethyl group at the 5' position contributes to its lipophilicity and potential for improved cellular uptake. The 2'-O-methyl modification enhances resistance to enzymatic degradation, making it suitable for therapeutic applications. The 3' position features a cyanoethyl phosphoramidite moiety, which is commonly used in oligonucleotide synthesis, allowing for the incorporation of this modified nucleoside into RNA or DNA strands. Overall, this compound exhibits properties that make it valuable in biochemical research and potential therapeutic applications, particularly in the field of nucleic acid chemistry.
Formula:C40H49N4O9P
InChI:InChI=1S/C40H49N4O9P/c1-27(2)44(28(3)4)54(51-25-11-23-41)53-36-34(52-38(37(36)49-7)43-24-22-35(45)42-39(43)46)26-50-40(29-12-9-8-10-13-29,30-14-18-32(47-5)19-15-30)31-16-20-33(48-6)21-17-31/h8-10,12-22,24,27-28,34,36-38H,11,25-26H2,1-7H3,(H,42,45,46)/t34-,36-,37-,38-,54?/m1/s1
InChI key:InChIKey=UVUOJOLPNDCIHL-XKZJCBTISA-N
SMILES:C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OC)[C@@H](O1)N2C(=O)NC(=O)C=C2)(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5
Synonyms:- 2'-O-Methyl-5'-O-DMT-Uridine-3'-CE-Phosphoramidite
- 5'-O-(4,4-Dimethoxytrityl)-2'-O-Methyluridine-3'-(2-Cyanoethyl-N,N-Diisopropyl)Phosphoramidite
- Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
- Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
- DMT-2-O-ME-U-CE Phosphoramidite
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 7 products.
DMT-2'-O-methyl-rU Phosphoramidite
CAS:Formula:C40H49N4O9PPurity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:760.825'-O-(4,4-Dimethoxytrityl)-2'-O-methyluridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
CAS:Formula:C40H49N4O9PPurity:98%Color and Shape:SolidMolecular weight:760.81225’-O-(4,4’-Dimethoxytrityl)-2’-O-Methyluridine-3’-(2-Cyanoethyl-N,N-Diisopropyl)Phosphoramidite
CAS:5’-O-(4,4’-Dimethoxytrityl)-2’-O-Methyluridine-3’-(2-Cyanoethyl-N,N-Diisopropyl)PhosphoramiditePurity:98%Molecular weight:760.81g/mol5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite
CAS:<p>5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite is a modified, phosphoramidite nucleoside. It is used in the synthesis of DNA and RNA. 5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite is an antiviral agent that inhibits viral replication by inhibiting viral protein synthesis. It has been shown to be active against HIV, Hepatitis B virus, and Hepatitis C virus. The compound also has anticancer properties and has been shown to inhibit tumor growth in animal models. 5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite is a novel synthetic nucleoside that can be used as an alternative to deoxyribonucleosides in the synthesis of DNA and RNA.</p>Formula:C40H49N4O9PPurity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:760.83 g/mol
