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CAS 110797-35-8

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NALPHA-FMOC-L-SERINE TERT-BUTYL ESTER

Description:
NALPHA-FMOC-L-SERINE TERT-BUTYL ESTER is a chemical compound commonly used in peptide synthesis and research. It is a derivative of the amino acid serine, modified with a fluorenylmethyloxycarbonyl (FMOC) protecting group and a tert-butyl ester. The FMOC group serves as a protective moiety for the amino group, allowing for selective reactions during peptide assembly, while the tert-butyl ester protects the carboxylic acid functionality. This compound is typically white to off-white in appearance and is soluble in organic solvents such as dichloromethane and dimethylformamide, but less soluble in water. Its stability under standard laboratory conditions makes it a valuable intermediate in the synthesis of peptides and other bioactive molecules. The presence of the FMOC group facilitates easy removal under mild basic conditions, which is advantageous in multi-step synthesis processes. Overall, NALPHA-FMOC-L-SERINE TERT-BUTYL ESTER is an important building block in the field of organic and medicinal chemistry.
Formula:C22H25NO5
InChI:InChI=1/C22H25NO5/c1-22(2,3)28-20(25)19(12-24)23-21(26)27-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19,24H,12-13H2,1-3H3,(H,23,26)/t19-/m0/s1
SMILES:CC(C)(C)OC(=O)[C@H](CO)N=C(O)OCC1c2ccccc2c2ccccc12
Synonyms:
  • N-Alpha-(9-Fluorenylmethoxycarbonyl)-L-Serine Alpha-T-Butyl Ester
  • Nalpha-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-L-Serine Tert-Butyl Ester
  • Fmoc-Ser-Otbu
  • tert-butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serinate
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