CAS 1108-68-5
:Cinobufotalin
Description:
Cinobufotalin is a chemical compound classified as a bufadienolide, which is a type of steroidal compound derived from toad venom, particularly from the Chinese toad Bufo gargarizans. It is known for its potential pharmacological properties, including anti-cancer, anti-inflammatory, and cardiotonic effects. The compound exhibits a complex structure characterized by a steroid backbone with specific functional groups that contribute to its biological activity. Cinobufotalin has garnered interest in traditional medicine and modern pharmacology, although its use is often accompanied by concerns regarding toxicity and side effects. Research into its mechanisms of action and therapeutic potential is ongoing, with studies exploring its effects on various cancer cell lines and its role in modulating immune responses. As with many natural products, the extraction and purification processes can influence its efficacy and safety profile, making it essential to conduct thorough investigations before clinical application. Overall, cinobufotalin represents a fascinating area of study within the realm of natural product chemistry and medicinal research.
Formula:C26H34O7
InChI:InChI=1S/C26H34O7/c1-14(27)32-21-20(15-4-5-19(29)31-13-15)24(3)10-7-17-18(26(24)22(21)33-26)8-11-25(30)12-16(28)6-9-23(17,25)2/h4-5,13,16-18,20-22,28,30H,6-12H2,1-3H3/t16-,17-,18+,20-,21+,22+,23+,24+,25-,26+/m0/s1
InChI key:InChIKey=KBKUJJFDSHBPPA-ZNCGZLKOSA-N
SMILES:C[C@]12[C@]3([C@](O3)([C@H](OC(C)=O)[C@@H]1C=4C=CC(=O)OC4)[H])[C@]5([C@](CC2)([C@]6(C)[C@](O)(CC5)C[C@@H](O)CC6)[H])[H]
Synonyms:- (3Beta,5Beta,15Beta,16Beta)-16-(Acetyloxy)-3,5-Dihydroxy-14,15-Epoxybufa-20,22-Dienolide
- (3β,5β,15β,16β)-16-(Acetyloxy)-14,15-epoxy-3,5-dihydroxybufa-20,22-dienolide
- 14,15-Epoxy-14H-cyclopenta[a]phenanthrene, bufa-20,22-dienolide deriv.
- 5-beta-Bufa-20,22-dienolide, 14,15-beta-epoxy-3-beta,5,16-beta-trihydroxy-, 16-acetate
- 5beta-Bufa-20,22-dienolide, 14,15beta-epoxy-3beta,5,16beta-trihydroxy-, 16-acetate
- 5β-Bufa-20,22-dienolide, 14,15β-epoxy-3β,5,16β-trihydroxy-, 16-acetate
- Bufa-20,22-dienolide, 16-(acetyloxy)-14,15-epoxy-3,5-dihydroxy-, (3beta,5beta,15beta,16beta)-
- Bufa-20,22-dienolide, 16-(acetyloxy)-14,15-epoxy-3,5-dihydroxy-, (3β,5β,15β,16β)-
- Cinobufotalin
- Cinobufotlin
- Nsc 90326
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Found 6 products.
Cinobufotalin
CAS:Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide production. Cinobufotalin is also an effective reversal agent for the multidrug resistance of tumors, it can reverse the adriamycin-resistance in Raji/ADR cells and the expression of P-gp and MRP-1 proteins. Cinobufotalin can promote the dendritic cells(DCs) derived from peripheral blood of patients with chronic hepatitis B to mature and effectively enhance its(the DCs') capabilities, therefore the treatment of cinobufotalin may potentiate the antiviral immunity of the patients with chronic hepatitis B(CHB).Formula:C26H34O7Purity:95%~99%Molecular weight:458.551Cinobufotalin
CAS:Cinobufotalin: Toad cardiac toxin, anti-HCC, induces apoptosis, reverses tumor drug resistance, boosts chronic hepatitis B immunity.Formula:C26H34O7Purity:99.52% - 99.94%Color and Shape:SolidMolecular weight:458.54Cinobufotalin
CAS:<p>Applications Cinobufotalin is used in combination with irinotecan and capecitabine for treating advanced colorectal cancer, study of the clinical curative effect in the treatment of cancer pain, pre-clinical evaluation of cinobufotalin as potential anti-lung cancer agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Qian, M., et al.: Chongqing Yixue, 44, 3112 (2015); Yu, B., et al.: Xiandai Zhongxiyi Jiehe Zazhi, 24, 3997 (2015); Kai, S., et al.: Biochem. Biophys. Res. Commun., 452, 768 (2014)<br></p>Formula:C26H34O7Color and Shape:NeatMolecular weight:458.54
