CAS 110816-78-9

N 556

Description:

N 556, with the CAS number 110816-78-9, is a chemical compound primarily used as a curing agent in the production of silicone elastomers. It is characterized by its ability to facilitate cross-linking reactions, enhancing the mechanical properties and thermal stability of silicone materials. N 556 typically exhibits low volatility and good compatibility with various silicone polymers, making it an effective additive in silicone formulations. The compound is often utilized in applications requiring high-performance materials, such as automotive, aerospace, and industrial sectors. Safety data sheets indicate that while it may pose certain health risks upon exposure, proper handling and safety precautions can mitigate these concerns. Overall, N 556 plays a crucial role in improving the durability and functionality of silicone-based products, contributing to their widespread use in diverse applications.

Formula: C₃₃H₃₈Cl₂N₂O₁₂

InChI: InChI=1/C33H36N2O12.2ClH/c1-3-41-32(39)27-15-21(36)29-23(10-7-12-25(29)46-27)43-17-19(45-31(38)20(35)9-5-6-14-34)18-44-24-11-8-13-26-30(24)22(37)16-28(47-26)33(40)42-4-2;;/h7-8,10-13,15-16,19-20H,3-6,9,14,17-18,34-35H2,1-2H3;2*1H/t20-;;/m0../s1

SMILES: CCOC(=O)c1cc(=O)c2c(cccc2o1)OCC(COc1cccc2c1c(=O)cc(C(=O)OCC)o2)OC(=O)[C@H](CCCCN)N.Cl.Cl

Synonyms:

• 1,3-Bis-(2-ethoxycarbonylchromon-5-yloxy)-2-(lysyloxy)propane
• Ky 556
• L-Lysine, 2-((2-(ethoxycarbonyl)-4-oxo-4H-1-benzopyran-5-yl)oxy)-1-(((2-(ethoxycarbonyl)-4-oxo-4H-1-benzopyran-5-yl)oxy)methyl)ethyl ester, dihydrochloride
• diethyl 5,5'-{[2-(L-lysyloxy)propane-1,3-diyl]bis(oxy)}bis(4-oxo-4H-chromene-2-carboxylate) dihydrochloride
• N-556

KY-556

CAS: 110816-78-9

KY-556 is a peptide inhibitor of the Kv1.2 voltage-gated potassium channel. It is a potent and selective blocker of Kv1.2 channels, with an IC50 of 0.4 μM and no activity against other voltage-gated potassium channels (Kv1.1, 1.3, 1.6). KY-556 has been shown to inhibit the proliferation of tumor cells by blocking Kv1.2 channels in cell culture experiments and in vivo in mice with implanted melanoma tumors. KY-556 also inhibits the release of inflammatory cytokines such as IL-6 and TNFα from human monocytes and macrophages, suggesting that it may have anti-inflammatory properties as well as tumor suppression capabilities.
KY-556 is synthesized using solid phase peptide synthesis on a Rink amide resin with an N-terminal lysine side chain protecting group and a COOH terminus acid side chain protecting group.

Formula: C₃₃H₃₈Cl₂N₂O₁₂

Purity: Min. 95%

Molecular weight: 725.6 g/mol

Ref: 3D-KEA81678

KY-556

CAS: 110816-78-9

KY-556 is a promising and orally-active pro-drug of disodium cromoglycate (DSCG). It also against allergic diseases.

Formula: C₃₃H₃₇ClN₂O₁₂

Color and Shape: Solid

Molecular weight: 689.11

Ref: TM-T15676