CAS 110880-55-2

(SAR9,MET(O2)11)-SUBSTANCE P

Description:

(SAR9,MET(O2)11)-Substance P, with the CAS number 110880-55-2, is a synthetic analog of the neuropeptide Substance P, which is involved in various physiological processes, including pain perception, inflammation, and stress responses. This compound is characterized by specific modifications to its amino acid sequence, notably the substitution of the ninth amino acid with sarcosine (SAR9) and the incorporation of a methionine sulfoxide (MET(O2)) at the eleventh position. These modifications enhance its stability and bioactivity compared to the natural peptide. The compound exhibits high affinity for neurokinin receptors, particularly NK1 receptors, which are implicated in pain signaling pathways. Its unique structure allows for potential therapeutic applications in pain management and neurogenic inflammation. Additionally, the presence of the methionine sulfoxide moiety may influence its pharmacokinetic properties, such as solubility and metabolic stability. Overall, (SAR9,MET(O2)11)-Substance P represents a significant advancement in the development of peptide-based therapeutics targeting neurokinin pathways.

Formula: C₆₄H₁₀₀N₁₈O₁₅S

InChI: InChI=1/C64H100N18O15S/c1-38(2)34-46(57(89)74-42(54(69)86)28-33-98(4,96)97)73-53(85)37-80(3)62(94)48(36-40-18-9-6-10-19-40)79-58(90)47(35-39-16-7-5-8-17-39)78-56(88)43(24-26-51(67)83)75-55(87)44(25-27-52(68)84)76-59(91)50-23-15-32-82(50)63(95)45(21-11-12-29-65)77-60(92)49-22-14-31-81(49)61(93)41(66)20-13-30-72-64(70)71/h5-10,16-19,38,41-50H,11-15,20-37,65-66H2,1-4H3,(H2,67,83)(H2,68,84)(H2,69,86)(H,73,85)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,88)(H,79,90)(H4,70,71,72)/t41-,42-,43-,44-,45-,46-,47-,48-,49-,50-/m0/s1

SMILES: CC(C)C[C@@H](C(=N[C@@H](CCS(=O)(=O)C)C(=N)O)O)N=C(CN(C)C(=O)[C@H](Cc1ccccc1)N=C([C@H](Cc1ccccc1)N=C([C@H](CCC(=N)O)N=C([C@H](CCC(=N)O)N=C([C@@H]1CCCN1C(=O)[C@H](CCCCN)N=C([C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N)O)O)O)O)O)O

Synonyms:

• Rpkpqqffsarlm(O2)
• H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met(O2)-Nh2
• Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met(O2)-Nh2
• [Sar9 ,Met(O2 )11 ]-Substance P Highly Specific Neurokinin Nk1 Receptor 97+%
• [Sar9,met(o2)11]-substancephighlyspecificneurokininnk1receptor
• substance P, Sar(9)-Met(O2)(11)-
• N~5~-(diaminomethylidene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanyl-N-methylglycyl-N-[(2S)-1-amino-4-(methylsulfonyl)-1-oxobutan-2-yl]-L-leucinamide
• Bhsar-sp
• [Sar9,Met(O2)11]SP
• Substance P, 9-(N-methylglycine)-, S,S-dioxide
• 9-Sarcosyl-11-methionine(o2)-substance p
• [Sar9]substance P sulphone
• Sarcosyl(9)-substance p sulfone
• [Sar9]SP sulphone
• 9-Sar-substance p sulfone
• [SAR9,MET(O2)11]-SUBSTANCE P?, >98%
• [Sar9, Met(O2)11
• [Sar9,Met(O2)11]-Substance P,Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met[O2]-NH2?, >98%
• [Sar9]SP sulfone
• (SAR9,MET(O2)11)-SUBSTANCE P USP/EP/BP
• Bolton-hunter reagent-substance p. sar(9)-Met(02)(11)
• (SAR9,MET(O2)11)-SUBSTANCE P
• L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Sar-L-Leu-4-(Methylsulfonyl)-L-Abu-NH2
• (2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfonyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide
• Bolton hunter-9-sar-11-Met(02)-substance p

(Sar⁹,Met(O₂)¹¹)-Substance P

CAS: 110880-55-2

This NK-1 receptor agonist exhibits the highest selectivity for NK-1 receptors in various bioassays. It evokes a concentration-dependent increase in mucus secretion and is much more potent than substance P (EC₅₀= 1.7 · 10-⁶M).

Formula: C₆₄H₁₀₀N₁₈O₁₅S

Purity: 96.3%

Color and Shape: White Lyophilisate

Molecular weight: 1393.68

Ref: 01-4013867

[Sar9,Met(O2)11]-Substance P

CAS: 110880-55-2

[Sar9,Met(O2)11]-Substance P

Purity: ≥98%

Molecular weight: 1393.66g/mol

Ref: 54-BUP01353

[Sar9, Met(O2)11]-Substance P

CAS: 110880-55-2

Formula: C₆₄H₁₀₀N₁₈O₁₅S

Molecular weight: 1393.66

Ref: 7W-GK9596

[Sar9,Met(O2)11]-Substance P

CAS: 110880-55-2

[Sar9,Met(O2)11]-Substance P (NA) is an agonist of NK1 receptor.

Formula: C₆₄H₁₀₀N₁₈O₁₅S

Purity: >99.99%

Color and Shape: Solid

Molecular weight: 1393.66

Ref: TM-T7828

(Sar 9,Met(O2)11)-Substance P

CAS: 110880-55-2

Substance P is a neuropeptide that is found in the brain and throughout the peripheral nervous system. It has been found to be involved in numerous physiological processes, including pain transmission, vasodilation, and inflammation. Substance P binds to neurokinin-1 receptor (NK-1R) with high affinity. NK-1R has been shown to be localized on cells of the submandibular gland and salivary gland. Techniques such as binding experiments have shown that substance P binds to NK-1R with high affinity and is therefore likely involved in salivation and other functions of these glands.

Formula: C₆₄H₁₀₀N₁₈O₁₅S

Purity: Min. 95%

Molecular weight: 1,393.66 g/mol

Ref: 3D-FS110428