CAS 11089-65-9

Tunicamycin

Description:

Tunicamycin is a nucleoside antibiotic that is primarily known for its ability to inhibit N-linked glycosylation in eukaryotic cells. It is produced by the bacterium *Streptomyces lysosuperificus* and is characterized by its complex structure, which includes a sugar moiety and an amino sugar. Tunicamycin acts by interfering with the synthesis of glycoproteins, which can lead to various cellular effects, including apoptosis in certain cell types. It is often used in research to study glycosylation processes and the role of glycoproteins in cellular functions. Tunicamycin is soluble in water and exhibits a relatively low toxicity profile, although it can be harmful at higher concentrations. Its mechanism of action and effects on cellular pathways make it a valuable tool in molecular biology and biochemistry, particularly in studies related to protein folding and cellular stress responses. However, due to its potent biological activity, careful handling and usage are recommended in laboratory settings.

Formula: C₃₇H₆₀N₄O₁₆

InChI: InChI=1/C30H46N4O16/c1-11(2)5-4-6-16(38)32-19-23(43)20(40)14(47-29(19)50-28-18(31-12(3)36)22(42)21(41)15(10-35)48-28)9-13(37)26-24(44)25(45)27(49-26)34-8-7-17(39)33-30(34)46/h4,6-8,11,13-15,18-29,35,37,40-45H,5,9-10H2,1-3H3,(H,31,36)(H,32,38)(H,33,39,46)/b6-4+/t13?,14-,15-,18-,19-,20+,21-,22-,23-,24+,25-,26-,27-,28-,29+/m1/s1

Synonyms:

• (E)-N-[(2R,3R,4R,5R,6R)-2-[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-6-[2-[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]-2-hydroxy-ethyl]-4,5-dihydroxy-tetrahydropyran-3-yl]-5-methyl-hex-2-enamide
• (E)-N-[(2S,3R,4R,5R,6R)-2-[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-6-[2-[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]-2-hydroxy-ethyl]-4,5-dihydroxy-tetrahydropyran-3-yl]-5-methyl-hex-2-enamide
• Nsc 177382
• MeSH ID: D014415
• Tunicamycin
• Nsc177382
• Aids-010655
• TUNICAMYCIN USP/EP/BP
• Tunicamycin from Streptomyces chartreusis
• Tunicamycin Mixture
• N-linked,DNA,UDP-HexNAc,inhibit,anti-cancer,Inhibitor,ATF6,synthesis,Influenza Virus,invasion,XBP-1,Bacterial,Fungal,glycoprotein,Tunicamycin,Antibiotic
• TUNICAMYCIN, STREPTOMYCES LYSOSUPERFICUS
• InSolution Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem
• Tunicamycin Streptomyces sp.
• tunicamycin from A streptomyces species
• tunicamycin from streptomyces sp.
• TunicaMycin coMplex
• isamycin
• tunicamycin from streptomyces lysosuperificus
• TunicaMycin froM StreptoMyces lysosuperficus
• Tunicamycin (n= 8,9,10,11)
• InSolution? Tunicamycin,
• TUNICAMYCIN FROM STREPTOMYCES LYSOSUPERFIUS NOV. SP.
• TUNICAMYCIN, STREPTOMYCES IYSOSUPERFICUS

Tunicamycin, 95%

CAS: 11089-65-9

A mixture of homologous nucleoside antibiotics

Formula: C₃₀H₄₆N₄O₁₆

Purity: 95%

Color and Shape: Powder

Molecular weight: 718.71

Ref: 02-J62217

Tunicamycin, 10 mg/ml in DMSO, sterile-filtered

CAS: 11089-65-9

Tunicamycin, 10mg/mL in DMSO, sterile-filtered; Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells. Also available as a 25 mM solution in DMSO. Antibacterial and antifungal. Blocks the formation of prote

Ref: 02-J67401

Tunicamycin

CAS: 11089-65-9

Formula: C₃₉H₆₄N₄O₁₆

Purity: ≥ 98%

Color and Shape: White to pale yellow powder

Molecular weight: 844.95

Ref: 7W-GA1622

Tunicamycin from Streptomyces sp.

CAS: 11089-65-9

Tunicamycin from Streptomyces sp.

Formula: C₃₇H₆₀N₄O₁₆

Purity: By hplc: a: 6.07%; b:34.99%; (Typical Value in Batch COA)

Color and Shape: off-white powder

Molecular weight: 816.89g/mol

Ref: 54-BIT1006

Tunicamycin

CAS: 11089-65-9

Tunicamycin is a mixture of antibiotics that inhibit N-linked glycosylation by blocking GlcNAc phosphotransferase (GPT).

Formula: C₃₉H₆₄N₄O₁₆

Purity: 98.77%

Color and Shape: White Crystalline Solid

Molecular weight: 844.94 (n=10)

Ref: TM-T13229

Tunicamycin

Controlled Product

CAS: 11089-65-9

Applications Tunicamycin is a competitive cell cycle inhibitor exhibiting antiungal properties.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Formula: (CH₂)nC₂₉H₄₄N₄O₁₆

Color and Shape: Neat

Ref: TR-T897268

Tunicamycin

CAS: 11089-65-9

Inhibitor of N-glycosylation in eukaryotes

Formula: C₃₇H₆₀N₄O₁₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 816.89

Ref: 3D-AT34338