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CAS 111011-53-1

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Efonidipine hydrochloride

Description:
Efonidipine hydrochloride is a calcium channel blocker primarily used in the treatment of hypertension and angina. It belongs to the dihydropyridine class of calcium antagonists, which selectively inhibit L-type calcium channels, leading to vasodilation and reduced cardiac workload. This compound exhibits dual action by blocking both L-type and T-type calcium channels, which may contribute to its efficacy in lowering blood pressure and improving cardiovascular function. Efonidipine is typically administered orally and is characterized by its relatively long half-life, allowing for once-daily dosing. The hydrochloride salt form enhances its solubility and stability. In terms of safety, like other calcium channel blockers, it may cause side effects such as dizziness, headache, or peripheral edema. Its pharmacokinetics and pharmacodynamics are influenced by factors such as age, liver function, and concurrent medications. Overall, Efonidipine hydrochloride represents a valuable therapeutic option in managing cardiovascular conditions, with a mechanism that targets calcium influx in vascular smooth muscle and cardiac tissues.
Formula:C34H38N3O7P·ClH
InChI:InChI=1S/C34H38N3O7P.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;1H
InChI key:InChIKey=OXVTXPCIJDYQIS-UHFFFAOYSA-N
SMILES:C(OCCN(CC1=CC=CC=C1)C2=CC=CC=C2)(=O)C=3C(C(=C(C)NC3C)P4(=O)OCC(C)(C)CO4)C5=CC(N(=O)=O)=CC=C5.Cl
Synonyms:
  • 3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester, P-oxide, monohydrochloride
  • 3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester, monohydrochloride
  • 1,3,2-Dioxaphosphorinane, 3-pyridinecarboxylic acid deriv.
  • NZ 105
  • 3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester, hydrochloride (1:1)
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