CAS 111025-46-8

Pioglitazone

Description:

Pioglitazone is an antidiabetic medication primarily used to manage type 2 diabetes mellitus. It belongs to the thiazolidinedione class of drugs, which function as agonists of the peroxisome proliferator-activated receptor gamma (PPAR-γ). This mechanism enhances insulin sensitivity in muscle and adipose tissue, thereby improving glucose uptake and utilization. Pioglitazone is typically administered orally and is often prescribed in conjunction with other antidiabetic agents. The substance is characterized by its chemical formula, which includes carbon, hydrogen, nitrogen, and oxygen atoms, and it exhibits a relatively high lipophilicity, influencing its absorption and distribution in the body. Common side effects may include weight gain, edema, and an increased risk of heart failure, necessitating careful patient monitoring. Additionally, pioglitazone has been associated with potential risks of bladder cancer, leading to specific recommendations regarding its use. Overall, pioglitazone plays a significant role in diabetes management, particularly for patients who are insulin-resistant.

Formula: C₁₉H₂₁ClN₂O₃S

InChI: InChI=1/C19H20N2O3S.ClH/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17;/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23);1H

InChI key: InChIKey=HYAFETHFCAUJAY-UHFFFAOYSA-N

SMILES: C(C1C(=O)NC(=O)S1)C2=CC=C(OCCC3=CC=C(CC)C=N3)C=C2

Synonyms:

• 5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione
• Pioglitazone base
• PINEPOLLEN
• KY-18
• 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
• 5-(4-[2-(5-ETHYL-PYRIDIN-2-YL)-ETHOXY]-BENZYL)-THIAZOLIDINE-2,4-DIONE
• 5-[4-[2-(5-ETHYL-2-PYRIDINYL)ETHOXY]PHENYL]METHYL-2,4-THIAZOLIDINEDIONE
• Pioglitazone and its intermeidates
• Pioglitazone free base
• PIOGLITAZONE HCL(5-[[4-[2-(5-ETHYLPYRIDIN-2-YL)ETHOXY]PHENYL]METHYL]THIAZOLIDINE-2,4-DIONE, HCL)
• 5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione hydrochloride (1:1)

Pioglitazone Hydrochloride

CAS: 111025-46-8, 112529-15-4

Formula: C₁₉H₂₀N₂O₃S·HCl

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 392.90

Ref: 3B-P1901

5-({4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione

CAS: 111025-46-8

Formula: C₁₉H₂₀N₂O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 356.4387

Ref: IN-DA00HBSN

Pioglitazone

CAS: 111025-46-8

Pioglitazone (U 72107) is a selective and oral PPARγ agonist with EC50 of 0.93 and 0.99 μM on human and mouse PPARγ, respectively . High-Quality, Low-Cost!

Formula: C₁₉H₂₀N₂O₃S

Purity: 95% - 99.57%

Color and Shape: White Powder

Molecular weight: 356.44

Ref: TM-T0214

Pioglitazone

CAS: 111025-46-8

Formula: C₁₉H₂₀N₂O₃S

Purity: ≥ 98%

Color and Shape: White to off-white powder or solid

Molecular weight: 356.44

Ref: 7W-GP2624

5-(4-(2-(5-Ethylpyridin-2-Yl)Ethoxy)Benzyl)Thiazolidine-2,4-Dione

CAS: 111025-46-8

5-(4-(2-(5-Ethylpyridin-2-Yl)Ethoxy)Benzyl)Thiazolidine-2,4-Dione

Purity: 99%

Molecular weight: 356.44g/mol

Ref: 54-OR1011705

Pioglitazone

CAS: 111025-46-8

Pioglitazone

Purity: ≥95%

Molecular weight: 356.44g/mol

Ref: 54-BUP11928

Pioglitazone-d4 Hydrochloride

Controlled Product

CAS: 111025-46-8, 1134163-29-3

Applications Pioglitazone-d4 is the labeled analogue of Pioglitazone (P469995), which shows antidiabetic activity in patients with type 2 diabetes mellitus.
References DeFronzo, R.A., et. al.: Diabetes, 62, 3920 (2013)

Formula: C₁₉H₁₇D₄ClN₂O₃S

Color and Shape: Neat

Molecular weight: 396.92

Ref: TR-P469997

Pioglitazone

Controlled Product

CAS: 111025-46-8

Applications Pioglitazone shows antidiabetic activity in patients with type 2 diabetes mellitus.
References DeFronzo, R.A., et. al.: Diabetes, 62, 3920 (2013)

Formula: C₁₉H₂₀N₂O₃S

Color and Shape: Neat

Molecular weight: 356.44

Ref: TR-P469995

Pioglitazone base

CAS: 111025-46-8

Agonist of peroxisome proliferator-activated receptor-γ (PPARγ), useful for the treatment and prevention of type 2 diabetes mellitus. It belongs to the class of thiazolidinediones (TZDs), which increase insulin sensitivity and glucose uptake in peripheral tissues. It reduces the risk of cardiovascular disease and was shown to atheroprotective and anti-inflammatory effects in animal models.

Formula: C₁₉H₂₀N₂O₃S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 356.44 g/mol

Ref: 3D-FP39372

PIOGLITAZONE

CAS: 111025-46-8

Formula: C₁₉H₂₀N₂O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 356.44

Ref: 10-F386732

Pioglitazone - Bio-X ™

CAS: 111025-46-8

Pioglitazone is a thiazolidinedione drug that is used in combination with diet change and exercise to treat glycemic levels in patients with type 2 diabetes mellitus. This drug is an agonist of peroxisome proliferator-activated receptor-gamma and increases glucose uptake. In animal studies, Pioglitazone has shown to have anti-inflammatory properties.

Formula: C₁₉H₂₀N₂O₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 356.44 g/mol

Ref: 3D-BP164273