CAS 1110766-97-6

(2E)-3-[2,6-Dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-2-propenoic acid

Description:

The chemical substance known as (2E)-3-[2,6-Dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-2-propenoic acid, with the CAS number 1110766-97-6, is a complex organic compound characterized by its multi-functional structure. It features a propenoic acid backbone, which contributes to its potential reactivity and biological activity. The presence of dichloro and methoxy groups indicates that it may exhibit unique electronic properties and solubility characteristics. Additionally, the thiazole and phenyl moieties suggest potential interactions with biological targets, making it of interest in medicinal chemistry. The hexoxy substituent may enhance lipophilicity, influencing its pharmacokinetic profile. Overall, this compound's intricate structure suggests it could have applications in pharmaceuticals, particularly in the development of targeted therapies or as a lead compound in drug discovery. However, specific biological activities and safety profiles would require further investigation through experimental studies.

Formula: C₂₉H₃₂Cl₂N₂O₅S

InChI: InChI=1S/C29H32Cl2N2O5S/c1-5-6-7-8-12-38-18(3)20-10-9-11-21(26(20)37-4)25-16-39-29(32-25)33-27(34)19-14-23(30)22(24(31)15-19)13-17(2)28(35)36/h9-11,13-16,18H,5-8,12H2,1-4H3,(H,35,36)(H,32,33,34)/b17-13+/t18-/m0/s1

InChI key: InChIKey=NOZIJMHMKORZBA-KJCUYJGMSA-N

SMILES: O(C)C1=C(C=CC=C1[C@@H](OCCCCCC)C)C=2N=C(NC(=O)C3=CC(Cl)=C(/C=C(/C(O)=O)\C)C(Cl)=C3)SC2

Synonyms:

• (2E)-3-[2,6-Dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-2-propenoic acid
• S 888711
• Lusutrombopag
• 2-Propenoic acid, 3-[2,6-dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-, (2E)-
• 2-Propenoic acid, 3-[2,6-dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-, (2E)-
• Mulpleo
• (E)-3-[2,6-dichloro-4-[4-[3-[(S)-1-hexyloxyethyl]-2-methoxyphenyl]thiazol-2-ylcarbamoyl]phenyl]-2-methylacrylic acid
• S888711;S 888711
• S888711
• Lusutrombopag S-888711

2-Propenoic acid, 3-[2,6-dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-, (2E)-

CAS: 1110766-97-6

Formula: C₂₉H₃₂Cl₂N₂O₅S

Purity: 97%

Color and Shape: Solid

Molecular weight: 591.5458

Ref: IN-DA008ZUX

Lusutrombopag

CAS: 1110766-97-6

Lusutrombopag

Purity: 98%

Molecular weight: 591.55g/mol

Ref: 54-OR1024364

Lusutrombopag

CAS: 1110766-97-6

Lusutrombopag

Purity: ≥98%

Molecular weight: 591.55g/mol

Ref: 54-BUP04663

Lusutrombopag

CAS: 1110766-97-6

Formula: C₂₉H₃₂Cl₂N₂O₅S

Molecular weight: 591.54

Ref: 4Z-L-164001

Lusutrombopag-d13

CAS: 1110766-97-6

Formula: C₂₉H₁₉D₁₃Cl₂N₂O₅S

Color and Shape: Off-White Solid

Molecular weight: 604.62

Ref: 4Z-L-164002

Lusutrombopag

CAS: 1110766-97-6

Lusutrombopag (Mulpleta) is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist for chronic liver disease (CLD) patients with

Formula: C₂₉H₃₂Cl₂N₂O₅S

Purity: 99.96%

Color and Shape: Solid

Molecular weight: 591.55

Ref: TM-TQ0223

Lusutrombopag-d13

Controlled Product

CAS: 1110766-97-6

Formula: C₂₉D₁₃H₁₉Cl₂N₂O₅S

Color and Shape: Neat

Molecular weight: 604.626

Ref: TR-L474987

Lusutrombopag

Controlled Product

CAS: 1110766-97-6

Applications Lusutrombopag is a newly discovered thrombopoietin receptor agonist used in the treatment of patients with chronic ITP.
References Katsube, T. et al.: Clin. Pharmacokinet., 55, 1423 (2016); Siegal, D. et al.: Semin. Hematol., 50, S18 (2013);

Formula: C₂₉H₃₂Cl₂N₂O₅S

Color and Shape: Neat

Molecular weight: 591.55

Ref: TR-L474985