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CAS 111113-75-8

:

5,6,7,8-tetrahydro-8-deazahomofolic acid

Description:
5,6,7,8-Tetrahydro-8-deazahomofolic acid is a synthetic derivative of folic acid, characterized by its structural modifications that enhance its biological activity and solubility. This compound features a tetrahydro structure, which contributes to its stability and reactivity. It is primarily recognized for its role as a cofactor in various enzymatic reactions, particularly in the synthesis of nucleotides and amino acids, making it significant in cellular metabolism and growth. The absence of a nitrogen atom in the 8-position distinguishes it from traditional folates, potentially influencing its interaction with enzymes and transport mechanisms. This compound is of interest in biochemical research and may have implications in therapeutic applications, particularly in the context of cancer treatment and metabolic disorders. Its solubility in aqueous solutions and stability under physiological conditions are important characteristics that facilitate its use in biological studies. As with many folate derivatives, it may also exhibit varying degrees of bioactivity, depending on the specific biological context and the presence of other co-factors.
Formula:C21H26N6O6
InChI:InChI=1/C21H26N6O6/c22-21-26-14-6-5-13(24-17(14)19(31)27-21)9-10-23-12-3-1-11(2-4-12)18(30)25-15(20(32)33)7-8-16(28)29/h1-4,13,15,23-24H,5-10H2,(H,25,30)(H,28,29)(H,32,33)(H3,22,26,27,31)/t13-,15+/m1/s1
Synonyms:
  • 5,6,7,8-Tdfa
  • (R)-N-(4-((2-(2-Amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(3,2-d)pyrimidin-6-yl)ethyl)amino)benzoyl)-L-glutamic acid
  • L-Glutamic acid, N-(4-((2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(3,2-d)pyrimidin-6-yl)ethyl)amino)benzoyl)-, (R)-
  • 5,6,7,8-Tetrahydro-8-deazahomofolic acid
  • N-[4-({2-[(6R)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[3,2-d]pyrimidin-6-yl]ethyl}amino)benzoyl]-L-glutamic acid
  • 8-Tdfa
  • 5,6,7,8 Tetrahydro 8 deazahomofolic acid,5,6,7,8Tetrahydro8deazahomofolic acid
  • L-Glutamic acid, N-[4-[[2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[3,2-d]pyrimidin-6-yl)ethyl]amino]benzoyl]-, (R)- (9CI)
  • 8-Tetrahydro-8-deazahomofolic acid
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