CAS 111119-28-9

gly-arg-gly-asp-ser-pro-lys

Description:

The chemical substance known as "gly-arg-gly-asp-ser-pro-lys" is a peptide composed of six amino acids: glycine (Gly), arginine (Arg), aspartic acid (Asp), serine (Ser), proline (Pro), and lysine (Lys). This peptide is often studied for its biological activity and potential applications in fields such as biochemistry and pharmacology. Its sequence suggests it may play a role in cell signaling, particularly in interactions with cell adhesion molecules and receptors. The presence of positively charged amino acids like arginine and lysine may contribute to its ability to interact with negatively charged cellular components. Additionally, the peptide's structure can influence its solubility, stability, and overall biological function. The CAS number 111119-28-9 uniquely identifies this specific peptide, facilitating its recognition in scientific literature and databases. Overall, gly-arg-gly-asp-ser-pro-lys exemplifies the complexity of peptide interactions in biological systems and highlights the importance of amino acid sequences in determining function.

Formula: C₂₈H₄₉N₁₁O₁₁

InChI: InChI=1/C28H49N11O11/c29-8-2-1-5-16(27(49)50)37-25(47)19-7-4-10-39(19)26(48)18(14-40)38-24(46)17(11-22(43)44)36-21(42)13-34-23(45)15(35-20(41)12-30)6-3-9-33-28(31)32/h15-19,40H,1-14,29-30H2,(H,34,45)(H,35,41)(H,36,42)(H,37,47)(H,38,46)(H,43,44)(H,49,50)(H4,31,32,33)/t15-,16-,17-,18-,19-/m0/s1

SMILES: C(CCN)C[C@@H](C(=O)O)N=C([C@@H]1CCCN1C(=O)[C@H](CO)N=C([C@H](CC(=O)O)N=C(CN=C([C@H](CCCNC(=N)N)N=C(CN)O)O)O)O)O

Synonyms:

• H-Gly-Arg-Gly-Asp-Ser-Pro-Lys-OH
• glycyl-N~5~-(diaminomethylidene)-L-ornithylglycyl-L-alpha-aspartyl-L-seryl-L-prolyl-L-lysine
• GRGDSPK
• GLY-ARG-GLY-ASP-SER-PRO-LYS
• EMD 56574
• Gly-Arg-Gly-Asp-Ser-Pro-Lys >=97% (HPLC)
• L-Lysine, glycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-prolyl-
• GRGDSPK, FIBRONECTIN ATTACHMENT PEPTIDE
• GLY-ARG-GLY-ASP-SER-PRO-LYS ACETATE
• glycyl- arginyl-glycyl-aspartyl-seryl-prolyl-lysine

H-Gly-Arg-Gly-Asp-Ser-Pro-Lys-OH

CAS: 111119-28-9

GRGDSPK, fibronectin analog.

Formula: C₂₈H₄₉N₁₁O₁₁

Purity: 98.6%

Molecular weight: 715.77

Ref: 01-4102088

Gly-Arg-Gly-Asp-Ser-Pro-Lys

CAS: 111119-28-9

Formula: C₂₈H₄₉N₁₁O₁₁

Molecular weight: 715.76

Ref: 7W-GK2645

GRGDSPK

CAS: 111119-28-9

GRGDSPK (EMD 56574) is an inhibitory peptide for RGD-mediated adhesion between integrin and extracellular matrix molecules.

Formula: C₂₈H₄₉N₁₁O₁₁

Purity: 98%

Color and Shape: Solid

Molecular weight: 715.76

Ref: TM-T7566

RGD Peptide GRGDSPK

CAS: 111119-28-9

GRGDSPK is the sequence found in cell binding region of fibronectin and many other proteins. The sequence, referred to as RGD, is critical for facilitating cell adhesion.-RGD peptide is an adhesive peptide which can be used in a biomaterial context to attach cells to a range of materials. RGD has many applications including as an antigen for integrin adhesion of thymocytes to thymic epithelial cells. RGD can be used as a blocking peptide to study bacteria and fibronectin. RGD can also be used on collagen-coated plates for study of integrins' role in progenitor cell differentiation. Delivery of RGD peptide inhibits bone mineralization in a dose-dependent manner so GRGDSPK is used to study the role of integrins in bone formation. The presence of RGD peptide dramatically alters bone morphology, with a disruption of osteoblast and mineralized matrix organisation. RGD is a vital research tool in bone formation and integrin.

Formula: C₂₈H₄₉N₁₁O₁₁

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 715.4 g/mol

Ref: 3D-CRB1000549

H-Gly-Arg-Gly-Asp-Ser-Pro-Lys-OH

CAS: 111119-28-9

H-Gly-Arg-Gly-Asp-Ser-Pro-Lys-OH is a peptide that has been shown to have chemotactic activity for monocytes and polymorphonuclear leucocytes, which are cells that participate in the inflammatory response. It also has biological properties that are reactive with hydroxyl groups and can be used to generate monoclonal antibodies. H-Gly-Arg-Gly-Asp-Ser-Pro-Lys-OH has been shown to stimulate the migration of galleria mellonella larvae, suggesting it may have potential as an antiinflammatory agent.

Formula: C₂₈H₄₉N₁₁O₁₁

Purity: Min. 95%

Molecular weight: 715.76 g/mol

Ref: 3D-FG109749

H-Gly-Arg-Gly-Asp-Ser-Pro-Lys-OH

CAS: 111119-28-9

GRGDSPK, fibronectin analog.

Formula: C₂₈H₄₉N₁₁O₁₁

Purity: 98.7%

Molecular weight: 715.77

Ref: 01-4011392