CymitQuimica logo

CAS 11116-31-7

:

Bleomycin A2

Description:
Bleomycin A2 is a glycopeptide antibiotic derived from the bacterium *Streptomyces verticillus*. It is primarily known for its antitumor properties and is used in the treatment of various cancers, including testicular cancer and Hodgkin's lymphoma. The compound exhibits a unique mechanism of action, which involves the induction of DNA strand breaks through the formation of free radicals upon binding to DNA. Bleomycin A2 is characterized by its complex structure, which includes a DNA-binding domain and an iron-binding moiety that facilitates its activity. It is typically administered via injection and can cause side effects such as pulmonary toxicity and skin reactions. The compound is notable for its ability to selectively target cancer cells while sparing normal tissues, although its therapeutic index can vary. Due to its specific action and side effects, careful monitoring is essential during treatment. Overall, Bleomycin A2 remains an important agent in oncological pharmacotherapy, contributing to the management of certain malignancies.
Formula:C55H84N17O21S3
InChI:InChI=1S/C55H83N17O21S3/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88)/p+1/t21-,22+,23+,24-,25-,29-,30+,34-,35-,36-,37+,38+,39-,40-,41-,42-,43-,53+,54-/m0/s1
InChI key:InChIKey=OYVAGSVQBOHSSS-UAPAGMARSA-O
SMILES:[C@H]([C@H](NC(=O)C1=NC([C@@H](NC[C@@H](C(N)=O)N)CC(N)=O)=NC(N)=C1C)C(N[C@@H]([C@H]([C@@H](C(N[C@H](C(NCCC2=NC(=CS2)C3=NC(C(NCCC[S+](C)C)=O)=CS3)=O)[C@@H](C)O)=O)C)O)C)=O)(O[C@H]4[C@@H](O[C@@H]5[C@@H](O)[C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O5)[C@@H](O)[C@H](O)[C@H](CO)O4)C6=CN=CN6
Synonyms:
  • Bleomycin A2
  • N1-[3-(Dimethylsulfonio)propyl]bleomycinamide
  • Pingyangmycin A2
  • Bleomycinamide, N1-[3-(dimethylsulfonio)propyl]-
  • Zhengguangmycin A2
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 1 products.
  • Demethylbleomycin A2 sulfate
    Biosynth
    + Info

    Demethylbleomycin A2 sulfate

    CAS:
    Demethylbleomycin A2 sulfate is an antineoplastic agent, which is derived from the bacterium Streptomyces verticillus. This compound functions by binding to DNA, inducing strand breaks and inhibiting DNA synthesis, ultimately leading to apoptosis or programmed cell death. Its mechanism of action involves the generation of free radicals, which cause oxidative damage to the DNA strands, impairing cellular replication and tumor growth.
    Formula:C55H84N17O21S3
    Purity:Min. 95%
    Molecular weight:1,415.6 g/mol

    Ref: 3D-LAA11631

    25mg
    1,048.00€
    50mg
    1,458.00€
    100mg
    2,271.00€