CAS 111278-00-3

anguinomycin B

Description:

Anguinomycin B, with the CAS number 111278-00-3, is a naturally occurring anthracycline antibiotic that exhibits notable antitumor properties. It is derived from the fermentation of certain Streptomyces species. This compound is characterized by its complex polycyclic structure, which includes a chromophore that is essential for its biological activity. Anguinomycin B functions primarily by intercalating into DNA, disrupting the replication process, and ultimately leading to cell death, making it a subject of interest in cancer research. Its mechanism of action is similar to that of other anthracyclines, such as doxorubicin, but it may exhibit a distinct profile in terms of efficacy and toxicity. Additionally, anguinomycin B has been studied for its potential use in combination therapies, enhancing the effectiveness of other anticancer agents. As with many natural products, the extraction and purification processes can be complex, and ongoing research aims to optimize its therapeutic applications while minimizing side effects.

Formula: C₃₂H₄₆O₆

InChI: InChI=1/C32H46O6/c1-8-27(15-16-28-13-10-14-30(35)38-28)19-22(3)12-9-11-21(2)17-24(5)31(36)26(7)32(37)25(6)18-23(4)20-29(33)34/h9-11,14-17,19-20,22,24-26,28,32,37H,8,12-13,18H2,1-7H3,(H,33,34)/b11-9+,16-15+,21-17+,23-20+,27-19+

Synonyms:

• (2E,10E,12E,16E,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-19-(6-oxo-3,6-dihydro-2H-pyran-2-yl)nonadeca-2,10,12,16,18-pentaenoic acid
• 2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-
• Anguinomycin B
• 19-[(3,6-Dihydro-6-oxo-2H-pyran)-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxononadeca-2,10,12,16,18-pentaenoic acid
• KR-2827A

Anguinomycin B

CAS: 111278-00-3

Anguinomycin B is an antitumor antibiotic (antibiotic) that exhibits high cytotoxicity against murine P388 leukemia cells.

Formula: C₃₂H₄₆O₆

Color and Shape: Solid

Molecular weight: 526.704

Ref: TM-TN9140