CAS 111358-88-4

Lestaurtinib

Description:

Lestaurtinib, with the CAS number 111358-88-4, is a small molecule that functions primarily as a protein kinase inhibitor. It is particularly noted for its activity against the FLT3 (Fms-like tyrosine kinase 3) receptor, which is often mutated in certain types of leukemia, especially acute myeloid leukemia (AML). The compound is characterized by its ability to interfere with cellular signaling pathways that promote cell proliferation and survival, making it a candidate for targeted cancer therapies. Lestaurtinib has been investigated in clinical trials for its efficacy in treating hematological malignancies. In terms of its chemical structure, it features a complex arrangement that includes various functional groups, contributing to its biological activity. The substance is typically administered in a pharmaceutical context, and its safety and efficacy profiles are evaluated through rigorous clinical testing. As with many kinase inhibitors, potential side effects may include impacts on normal cellular functions, necessitating careful monitoring during treatment.

Formula: C₂₆H₂₁N₃O₄

InChI: InChI=1/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18?,25-,26-/m0/s1

InChI key: InChIKey=UIARLYUEJFELEN-LROUJFHJSA-N

SMILES: C[C@]12N3C=4C=5N(C=6C(C5C7=C(C4C=8C3=CC=CC8)CNC7=O)=CC=CC6)[C@](O1)(C[C@@]2(CO)O)[H]

Synonyms:

• (5S,6S)-6-hydroxy-6-(hydroxymethyl)-5-methyl-5,6,7,8,14,15-hexahydro-13H-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]cyclopenta[e]-as-indacen-13-one
• (5S,6S,8R)-6-hydroxy-6-(hydroxymethyl)-5-methyl-5,6,7,8,14,15-hexahydro-13H-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]cyclopenta[e]-as-indacen-13-one
• (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:321kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
• (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
• 9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-, (9S,10S,12R)-
• 9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-, [9S-(9α,10β,12α)]-
• A 154475.0
• Cep 701
• Kt 5555
• NSC 621867
• Sp 924
• (9S-(9α,10β,12α))-2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxyMethyl)-9-Methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
• CEP-701 hydrate
• KT-5555 hydrate
• lestaurtinib
• Apalutamide
• SPM-924

Lestaurtinib

CAS: 111358-88-4

Formula: C₂₆H₂₁N₃O₄

Purity: ≥ 98.0%

Color and Shape: White to off-white solid

Molecular weight: 439.47

Ref: 7W-GP2428

Lestaurtinib

CAS: 111358-88-4

Lestaurtinib

Formula: C₂₆H₂₁N₃O₄

Purity: By hplc: 98.43% (Typical Value in Batch COA)

Color and Shape: white powder

Molecular weight: 439.46g/mol

Ref: 54-BIL2000

Lestaurtinib

CAS: 111358-88-4

Lestaurtinib (CEP 701) is a FLT3 inhibitor that inhibits the phosphorylation of RPTKs and can be used to study leukemia.

Formula: C₂₆H₂₁N₃O₄

Purity: 99.17%

Color and Shape: Off-White Solid

Molecular weight: 439.46

Ref: TM-T15738

Lestaurtinib

CAS: 111358-88-4

Formula: C₂₆H₂₁N₃O₄

Molecular weight: 439.47

Ref: 4Z-L-123001

Lestaurtinib

CAS: 111358-88-4

Lestaurtinib is a multitarget tyrosine kinase inhibitor of the JAK, FLT-3 and TrkA families of tyrosine kinases at nanomolar concentrations. It inhibits proliferation and induces apoptosis in vitro. Lestaurtinib is a FDA approved orphan drug for acute myeloid leukemia.

Formula: C₂₆H₂₁N₃O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 439.46 g/mol

Ref: 3D-FL24870

Lestaurtinib

Controlled Product

CAS: 111358-88-4

Stability Photosensitive
Applications It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML).

Formula: C₂₆H₂₁N₃O₄

Color and Shape: Neat

Molecular weight: 439.46

Ref: TR-L329800