CAS 111447-35-9

O(6)-(2-hydroxyethyl)-2'-deoxyguanosine

Description:

O(6)-(2-hydroxyethyl)-2'-deoxyguanosine is a modified nucleoside that features a 2-hydroxyethyl group attached to the O(6) position of the guanine base. This modification can influence the nucleoside's biochemical properties, including its interaction with DNA and RNA, as well as its potential role in cellular processes. The presence of the hydroxyethyl group may enhance solubility and alter the nucleoside's hydrogen bonding capabilities, potentially affecting its pairing with complementary nucleotides. This compound is of interest in the field of medicinal chemistry and molecular biology, particularly in studies related to DNA damage and repair mechanisms, as well as in the development of therapeutic agents. Its CAS number, 111447-35-9, uniquely identifies this substance in chemical databases, facilitating research and regulatory processes. Overall, O(6)-(2-hydroxyethyl)-2'-deoxyguanosine serves as a valuable tool for understanding nucleic acid chemistry and the implications of chemical modifications on genetic material.

Formula: C₁₂H₁₇N₅O₅

InChI: InChI=1/C12H17N5O5/c13-12-15-10-9(11(16-12)21-2-1-18)14-5-17(10)8-3-6(20)7(4-19)22-8/h5-8,18-20H,1-4H2,(H2,13,15,16)/t6-,7+,8+/m0/s1

Synonyms:

• 2'-Deoxy-O(6)-(2-hydroxyethyl)guanosine
• O6-Hedg
• Ethanol, 2-((2-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)-9H-purin-6-yl)oxy)-
• 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-(2-hydroxyethoxy)-9H-purin-2-amine
• O(6)-(2-Hydroxyethyl)-2'-deoxyguanosine

O6-(2-Hydroxyethyl)-2'-deoxyguanosine

Controlled Product

CAS: 111447-35-9

Applications A DNA adduct from N-nitrosodiethanolamine and related β-oxidized nitrosamines. It is produced by nitrosamine bident carcinogens.
References Wilson, V., et al.: Cancer Res., 48, 2156 (1988), Gorelick, N., et al.: Mutat. Res., 288, 5 (1993), Niedernhofer, L., wt al.: Chem. Res. Toxicol., 10, 556 (1997),

Formula: C₁₂H₁₇N₅O₅

Color and Shape: Neat

Molecular weight: 311.29

Ref: TR-H942020

O6-(2-Hydroxyethyl-d4)-2'-deoxyguanosine

Controlled Product

CAS: 111447-35-9

Applications A labelled DNA adduct from N-nitrosodiethanolamine and related β-oxidized nitrosamines. It is produced by nitrosamine bident carcinogens.
References Wilson, V., et al.: Cancer Res., 48, 2156 (1988), Gorelick, N., et al.: Mutat. Res., 288, 5 (1993), Niedernhofer, L., wt al.: Chem. Res. Toxicol., 10, 556 (1997),

Formula: C₁₂D₄H₁₃N₅O₅

Color and Shape: Neat

Molecular weight: 315.318

Ref: TR-H942022

O6-(2-Hydroxyethyl)-2′-deoxyguanosine

CAS: 111447-35-9

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Formula: C₁₂H₁₇N₅O₅

Purity: Min. 95%

Molecular weight: 311.29 g/mol

Ref: 3D-LEA44735