CRM1-IN-3, identified by its CAS number 1114628-25-9, is a small molecule inhibitor that specifically targets the CRM1 protein, also known as exportin 1. This protein plays a crucial role in the nuclear export of various proteins and RNA, making it a significant player in cellular processes and a potential target for cancer therapy. The compound is characterized by its ability to disrupt the CRM1-mediated nuclear export pathway, leading to the accumulation of tumor suppressor proteins and other regulatory factors in the nucleus, which can induce apoptosis in cancer cells. CRM1-IN-3 is typically studied in the context of its pharmacological properties, including its efficacy, selectivity, and potential side effects. Its chemical structure includes specific functional groups that contribute to its binding affinity and inhibitory action against CRM1. As research continues, CRM1-IN-3 may provide insights into novel therapeutic strategies for various malignancies and other diseases associated with dysregulated nuclear export.

CRM1-IN-3

1114628-25-9: CRM1-IN-3, identified by its CAS number 1114628-25-9, is a small molecule inhibitor that specifically targets the CRM1 protein, also known as exportin 1. This protein plays a crucial role in the nuclear export of various proteins and RNA, making it a significant player in cellular processes and a potential target for cancer therapy. The compound is characterized by its ability to disrupt the CRM1-mediated nuclear export pathway, leading to the accumulation of tumor suppressor proteins and other regulatory factors in the nucleus, which can induce apoptosis in cancer cells. CRM1-IN-3 is typically studied in the context of its pharmacological properties, including its efficacy, selectivity, and potential side effects. Its chemical structure includes specific functional groups that contribute to its binding affinity and inhibitory action against CRM1. As research continues, CRM1-IN-3 may provide insights into novel therapeutic strategies for various malignancies and other diseases associated with dysregulated nuclear export.

<p>CRM1-IN-3 (B28), a noncovalent inhibitor of CRM1, is utilized in the research of protein localization and tumor studies [1].</p>

CAS 1114628-25-9

CRM1-IN-3

CRM1-IN-3

Ref: TM-T86090