CAS 111469-81-9

naltrindole hydrochloride

Description:

Naltrindole hydrochloride is a selective antagonist of the delta-opioid receptor, which is part of the opioid receptor family involved in pain modulation and various physiological processes. It is primarily used in research settings to study the role of delta-opioid receptors in pain and addiction. The compound is characterized by its ability to inhibit the effects of endogenous and exogenous opioids at the delta receptor site, making it a valuable tool in pharmacological studies. Naltrindole hydrochloride is typically presented as a white to off-white crystalline powder and is soluble in water and organic solvents, which facilitates its use in various experimental protocols. Its molecular structure includes a core that allows for specific binding to the delta-opioid receptor, contributing to its selectivity and efficacy. Safety data indicate that while it is generally well-tolerated in research applications, appropriate handling and usage guidelines should be followed to mitigate any potential risks associated with its pharmacological properties.

Formula: C₂₆H₂₇ClN₂O₃

InChI: InChI=1/C26H26N2O3.ClH/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14;/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2;1H

InChI key: InChIKey=KNJKRQXCFJCQHC-IDRHMUJXSA-N

SMILES: O[C@]12[C@@]34C=5C(O[C@]3(C6=C(C1)C=7C(N6)=CC=CC7)[H])=C(O)C=CC5C[C@]2(N(CC8CC8)CC4)[H].Cl

Synonyms:

• 4,8-Methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol, 7-(cyclopropylmethyl)-5,6,7,8,14,14b-hexahydro-, hydrochloride (1:1), (4bS,8R,8aS,14bR)-
• 4,8-Methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol, 7-(cyclopropylmethyl)-5,6,7,8,14,14b-hexahydro-, monohydrochloride, (4bS,8R,8aS,14bR)-
• 7-(cyclopropylmethyl)-5,6,7,8,14,14b-hexahydro-4,8-methano[1]benzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol hydrochloride
• Naltrindole hydrochloride
• NALTRINDOLE HYDROCHLORIDE (NTI) NON-PEPT IDE DELTA OPI
• 17-(CYCLOPROPYLMETHYL)-6,7-DEHYDRO-4,5A-EPOXY-3,14-DIHYDROXY-6,7-2',3'-INDOLOMORPHINAN HYDROCHLORIDE
• NTI HYDROCHLORIDE
• NTI
• NALTRIDOLE HYDROCHLORIDE
• 17-(Cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinanhydrochloride
• 17-(Cyclopropylmethyl)-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan hydrochloride

Naltrindole hydrochloride

CAS: 111469-81-9

Formula: C₂₆H₂₆N₂O₃·HCl

Molecular weight: 450.96

Ref: 7W-GP4149

Naltrindole Hydrochloride -D4

Controlled Product

CAS: 111469-81-9

Formula: C₂₆H₂₂D₄N₂O₃•HCl

Color and Shape: Neat

Molecular weight: 454.98

Ref: TR-N285772

Naltrindole Hydrochloride

Controlled Product

CAS: 111469-81-9

Applications Naltrindole Hydrochloride is a δ opioid (DOR) receptor antagonist.
References Portoghese, P., et al.: J. Med. Chem., 33, 1714 (1990);

Formula: C₂₆H₂₆N₂O₃·HCl

Color and Shape: Neat

Molecular weight: 451.00

Ref: TR-N285773

Naltrindole Hydrochloride -D4

Controlled Product

CAS: 111469-81-9

Naltrindole is a potent κ-opioid receptor agonist that has been shown to be effective in animal models of diabetic neuropathy and cardiac injury. Naltrindole binds to the κ-opioid receptor, which is found in the central nervous system and peripheral tissues. It also interacts with other receptors, including the epidermal growth factor receptor (EGFR) and creatine kinase. This drug has been shown to have antinociceptive properties in animal models of pain. Naltrindole inhibits locomotor activity, but does not affect muscle contraction or relaxation. The clinical relevance of this drug is being investigated for use in treating chronic pain conditions.

Formula: C₂₆H₂₂D₄N₂O₃·HCl

Purity: Min. 95%

Molecular weight: 418.52 g/mol

Ref: 3D-LEA46981