CAS 1115-52-2

S-(1,2-dicarboxyethyl)glutathione

Description:

S-(1,2-Dicarboxyethyl)glutathione, with the CAS number 1115-52-2, is a derivative of glutathione, a tripeptide composed of glutamate, cysteine, and glycine. This compound features a dicarboxyethyl group attached to the sulfur atom of the cysteine residue, which imparts unique chemical properties. It is characterized by its ability to participate in redox reactions, acting as an antioxidant that helps protect cells from oxidative stress. The presence of multiple carboxyl groups enhances its solubility in water and contributes to its reactivity. This compound is often studied in the context of biochemical pathways, particularly those involving detoxification and cellular defense mechanisms. Its role in cellular metabolism and potential therapeutic applications, especially in the context of diseases associated with oxidative damage, make it a subject of interest in both biochemistry and pharmacology. Additionally, its stability and reactivity can be influenced by environmental factors such as pH and temperature, which are important considerations in experimental settings.

Formula: C₁₅H₂₃N₃O₁₀S

InChI: InChI=1/C15H23N3O10S/c16-7(14(25)26)1-2-10(19)18-8(13(24)17-6-12(22)23)3-4-29-9(15(27)28)5-11(20)21/h7-9H,1-6,16H2,(H,17,24)(H,18,19)(H,20,21)(H,22,23)(H,25,26)(H,27,28)/t7-,8-,9?/m0/s1

SMILES: C(CC(=N[C@@H](CCSC(CC(=O)O)C(=O)O)C(=NCC(=O)O)O)O)[C@@H](C(=O)O)N

Synonyms:

• H-Glu(Cys(1,2-dicarboxyethyl)-Gly-OH)-OH
• S-(1,2-dicarboxyethyl)-L-cysteinyl-N-L-gamma-glutamylglycine
• L-gamma-glutamyl-S-(1,2-dicarboxyethyl)-L-homocysteylglycine

S-(1,2-Dicarboxyethyl)glutathione

CAS: 1115-52-2

Dicarboxyethyl-glutathione is found in considerable amounts in rat liver, heart, and lens. It shows anti-inflammatory and anti-anaphylactic effects in vivo and inhibits histamine release from rat mast cells in vitro.

Formula: C₁₄H₂₁N₃O₁₀S

Purity: 97.4%

Color and Shape: White Lyophilisate

Molecular weight: 423.4

Ref: 01-4025062

2-S-Glutathionyl Succinate (Mixture of Diastereomers)

Controlled Product

CAS: 1115-52-2

Formula: C₁₄H₂₁N₃O₁₀S

Color and Shape: Neat

Molecular weight: 423.396

Ref: TR-D436253

S-(1,2-Dicarboxyethyl)glutathione

CAS: 1115-52-2

S-(1,2-Dicarboxyethyl)glutathione is a glutathione analogue that has been shown to prevent acetaminophen-induced hepatotoxicity in mice. It inhibits the reaction between acetaminophen and hepatic microsomal cytochrome P450 enzymes, which prevents the formation of toxic metabolites. S-(1,2-Dicarboxyethyl)glutathione also inhibits the production of serotonin by inhibiting the enzyme tryptophan hydroxylase. This drug has an anticoagulant effect by preventing the conversion of prothrombin to thrombin. S-(1,2-Dicarboxyethyl)glutathione also affects growth factors and collagen synthesis by affecting both epidermal growth factor (EGF) and fibroblast growth factor (FGF). The optimum pH for this drug is at 7.0.

Formula: C₁₄H₂₁N₃O₁₀S

Purity: Min. 95%

Molecular weight: 423.4 g/mol

Ref: 3D-FD108465