CAS 1116086-09-9

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-<span class="text-smallcaps">L</smallcap>-phenylalanyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-N⁶-(triphenylmethyl)-<smallcap>L</span>-lysinamide

Description:

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-N^6-(triphenylmethyl)-L-lysinamide, with CAS number 1116086-09-9, is a synthetic compound primarily used in peptide chemistry and drug development. This substance features a complex structure that includes a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is commonly employed in solid-phase peptide synthesis to protect amino groups. The presence of a nitrophenoxycarbonyl moiety suggests potential applications in targeted drug delivery or as a prodrug, where the nitro group may play a role in bioactivity or stability. The triphenylmethyl group indicates a high degree of steric hindrance, which can influence the compound's reactivity and solubility. Overall, this compound is characterized by its intricate molecular architecture, which is designed to facilitate specific interactions in biochemical applications, making it a valuable tool in the fields of medicinal chemistry and biochemistry.

Formula: C₆₃H₅₇N₅O₉

InChI: InChI=1S/C63H57N5O9/c69-59(65-49-34-32-45(33-35-49)42-76-62(72)77-51-38-36-50(37-39-51)68(73)74)57(31-17-18-40-64-63(46-21-7-2-8-22-46,47-23-9-3-10-24-47)48-25-11-4-12-26-48)66-60(70)58(41-44-19-5-1-6-20-44)67-61(71)75-43-56-54-29-15-13-27-52(54)53-28-14-16-30-55(53)56/h1-16,19-30,32-39,56-58,64H,17-18,31,40-43H2,(H,65,69)(H,66,70)(H,67,71)/t57-,58-/m0/s1

InChI key: InChIKey=BACWIDRMGLDCKA-YQOHNZFASA-N

SMILES: C(NCCCC[C@H](NC([C@H](CC1=CC=CC=C1)NC(OCC2C=3C(C=4C2=CC=CC4)=CC=CC3)=O)=O)C(NC5=CC=C(COC(OC6=CC=C(N(=O)=O)C=C6)=O)C=C5)=O)(C7=CC=CC=C7)(C8=CC=CC=C8)C9=CC=CC=C9

Synonyms:

• L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-N6-(triphenylmethyl)-
• Fmoc-PheLys(Trt)-PAB-PNP
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-N6-(triphenylmethyl)-L-lysinamide
• FMoc-Phe-Lys(Trt)-PAB-PNP

Fmoc-Phe-Lys(Trt)-PAB-PNP

CAS: 1116086-09-9

Formula: C₆₃H₅₇N₅O₉

Purity: 98%

Color and Shape: Solid

Molecular weight: 1028.1548

Ref: IN-DA01EN6X

Fmoc-Phe-Lys(Trt)-PAB-PNP

CAS: 1116086-09-9

Fmoc-Phe-Lys(Trt)-PAB-PNP

Purity: ≥95%

Ref: 54-OR471216

Fmoc-Phe-Lys(Trt)-PAB-PNP

CAS: 1116086-09-9

Fmoc-Phe-Lys(Trt)-PAB-PNP is a cleavable linker for antibody-drug conjugate (ADC) synthesis, specifically designed for use in ADC synthesis.

Formula: C₆₃H₅₇N₅O₉

Purity: 98%

Color and Shape: Solid

Molecular weight: 1028.175

Ref: TM-T17980

Fmoc-Phe-Lys(trt)-PAB-PNP

CAS: 1116086-09-9

Fmoc-Phe-Lys(trt)-PAB-PNP is a synthetic peptide designed to activate the human serotonin receptor. It is a high purity, potent activator of the serotonin 5HT2A receptor. Fmoc-Phe-Lys(trt)-PAB-PNP binds to the receptor and causes conformational changes in its structure that allow it to bind to G proteins that activate phospholipase C (PLC) and increase intracellular calcium concentrations. This peptide is an inhibitor of the serotonin 5HT2A receptor, as it blocks binding of serotonin or other agonists such as LSD or DOI.

Formula: C₆₃H₅₇N₅O₉

Purity: Min. 95%

Molecular weight: 1,028.2 g/mol

Ref: 3D-RUB08609